A portable plug-and-play syringe pump using passive valves for microfluidic applications
A portable plug-and-play syringe pump using passive valves for microfluidic applications
复制标题
一种使用被动阀的便携式即插即用注射泵，用于微流体应用
DOI：
10.1016/j.snb.2019.127331
复制
发表时间：
2020-02-01
影响因子：
8.4
通讯作者：
Ji, Aimin
中科院分区：
文献类型：
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作者：
Zhang, Xinjie;Xia, Kang;Ji, Aimin
便携式和自主泵是低成本的点护理测试（POCT）应用在微流体领域的关键需求。在微流控实验室中，商用泵（如注射泵、压力泵或蠕动泵）被广泛用于精确的流体输送，但由于其体积庞大且成本高，无法集成到小型化的微流控设备中。在这里，我们提出了一种便携式即插即用的注射器泵，具有自主流量输送功能。存储在泵中的流体由专门设计的压缩弹簧机构驱动，由包含三个被动阀的微流体流量调节芯片控制。重要的是，通过被动阀的液体流量不受弹簧压缩力变化引起的流体压力的影响，通过泵内的微流体流量调节芯片实现恒定流量的自动调节。该特性已用于在t型结微流控混合器中为被动样品混合或惯性微流控芯片中的高效颗粒分离提供稳定的流体注入。我们设想自给自足的便携式即插即用注射泵将促进微流控系统的小型化，这将为微流控技术的大规模应用提供光明。
Portable and autonomous pumps are in critical demand for low-cost point-of-care testing (POCT) applications in microfluidic fields. In microfluidic laboratories, commercial pumps (e.g., syringe pumps, pressure pumps, or peristaltic pumps) are widely used for precise fluid delivery, however they can't be integrated into miniaturized microfluidic devices due to their bulky sizes and high costs. Here, we propose a portable plug-and-play syringe pump with autonomous flow delivery function. Fluid stored in the pump is driven by a specially designed compression spring mechanism, and it is controlled by a microfluidic flow regulatory chip which contains three passive valves. Importantly, the liquid flow rate through the passive valve is independent of the fluidic pressure induced by the varied spring compression force, and constant flow autoregulation is realized through the microfluidic flow regulatory chip in the pump. This feature has been used for providing steady fluid infusions for passive sample mixing in a T-junction microfluidic mixer or high efficiency particle separation in an inertial microfluidic chip. We envision that the self-sufficient and portable plug-and-play syringe pump will facilitate the miniaturization of microfluidic systems which will shed light on the large-scale application of microfluidic technologies.