Comparison of parathyroid hormone and strontium ranelate in combination with whole-body vibration in a rat model of osteoporosis
Comparison of parathyroid hormone and strontium ranelate in combination with whole-body vibration in a rat model of osteoporosis
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DOI：
10.1007/s00774-016-0736-0
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发表时间：
2017-01-01
影响因子：
3.3
通讯作者：
Tezval, M.
中科院分区：
文献类型：
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作者：
Hoffmann, D. B.;Sehmisch, S.;Tezval, M.
我们在骨质疏松症大鼠模型中研究了全身垂直振动 (WBVV) 与主要骨合成代谢甲状旁腺激素 (PTH) 和主要抗吸收雷奈酸锶 (SR) 的组合效应。对 76 只三个月大的 Sprague-Dawley 大鼠（OVX，n = 76；非 OVX，n = 12）进行了卵巢切除术。 8周后，将卵巢切除的大鼠分为6组。一组（OVX + PTH）每天接受 PTH 注射（40 μg/kg 体重/天），持续 6 周。另一组（OVX + SR）饲喂添加 SR 的食物（600 毫克/千克体重/天）。三组（OVX + VIB、OVX + PTH + VIB 和 OVX + SR + VIB）每天接受 WBVV 治疗两次，频率为 70 Hz，持续 15 分钟。两组（OVX + PTH + VIB、OVX + SR + VIB）分别额外接受 PTH 和 SR 治疗。卵巢切除后14周处死大鼠。移除腰椎和股骨以进行生物力学和形态学评估。 PTH 在生物力学和结构特性方面产生了统计上显着的改善，包括骨矿物质密度 (BMD) 和小梁骨质量。相比之下，SR 治疗效果轻微，仅对皮质厚度有显着影响。 SR 并未对生物力学特性产生显着改善。 WBVV 作为单一或辅助疗法没有产生显着的改善。总之，振动疗法作为单一或双重治疗对骨质疏松症影响的骨骼没有显着影响。 PTH 显着改善骨质疏松病例的骨质量，并且优于 SR 治疗。
We investigated the combinatorial effects of whole-body vertical vibration (WBVV) with the primarily osteoanabolic parathyroid hormone (PTH) and the mainly antiresorptive strontium ranelate (SR) in a rat model of osteoporosis. Ovariectomies were performed on 76 three-month-old Sprague-Dawley rats (OVX, n = 76; NON-OVX, n = 12). After 8 weeks, the ovariectomized rats were divided into 6 groups. One group (OVX + PTH) received daily injections of PTH (40 A mu g/kg body weight/day) for 6 weeks. Another group (OVX + SR) was fed SR-supplemented chow (600 mg/kg body weight/day). Three groups (OVX + VIB, OVX + PTH + VIB, and OVX + SR + VIB) were treated with WBVV twice a day at 70 Hz for 15 min. Two groups (OVX + PTH + VIB, OVX + SR + VIB) were treated additionally with PTH and SR, respectively. The rats were killed at 14 weeks post-ovariectomy. The lumbar vertebrae and femora were removed for biomechanical and morphological assessment. PTH produced statistically significant improvements in biomechanical and structural properties, including bone mineral density (BMD) and trabecular bone quality. In contrast, SR treatment exerted mild effects, with significant effects in cortical thickness only. SR produced no significant improvement in biomechanical properties. WBVV as a single or an adjunctive therapy produced no significant improvements. In conclusion, vibration therapy administered as a single or dual treatment had no significant impact on bones affected by osteoporosis. PTH considerably improved bone quality in osteoporosis cases and is superior to treatment with SR.