Learning and memorization impairment in childhood chronic fatigue syndrome manifesting as school phobia in Japan
Learning and memorization impairment in childhood chronic fatigue syndrome manifesting as school phobia in Japan
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DOI：
10.1016/j.braindev.2003.10.004
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发表时间：
2004-10-01
影响因子：
1.7
通讯作者：
Mabe, H
中科院分区：
文献类型：
--
作者：
Miike, T;Tomoda, A;Mabe, H
在过去的15年里，我们试图了解日本儿童慢性疲劳综合征（CCFS）的病理生理学。在这种情况下，两个主要症状是重要的：容易疲劳和干扰学习和记忆。在CCFS患者中，我们临床评估了自主神经系统功能、激素分泌（褪黑激素、皮质醇和3-内啡肽）的昼夜节律、核心体温和睡眠-觉醒模式。大多数患者表现出自主神经系统功能障碍和昼夜节律紊乱，类似于在时差中观察到的。放射成像研究（SPECT、Xe-CT和MRS）显示额叶和丘脑区域血流量减少，额叶胆碱蓄积。分析CCFS的实验室检查结果与临床症状的关系。(C)2004 Elsevier B. V.保留所有权利。
For the last 15 years, we have tried to understand the pathophysiology of childhood chronic fatigue syndrome (CCFS) in Japan. In this condition, two major symptoms are important: easy fatigability and disturbed learning and memorization. In CCFS patients we clinically evaluated autonomic nervous system function, circadian rhythm of hormonal secretion (melatonin, cortisol and 3-endorphin), core body temperature, and sleep-wake pattern. Most patients showed autonomic nervous system dysfunction and circadian rhythm disturbances, similar to those observed in jet lag. Radiological imaging studies (SPECT, Xe-CT, and MRS) revealed decreased blood flow in the frontal and thalamic areas, and accumulation of choline in the frontal lobe. We analyzed the relationship between the laboratory data and clinical symptoms in CCFS. (C) 2004 Elsevier B.V. All rights reserved.