MULTIPLE-SCLEROSIS SIBLING PAIRS - CLUSTERED ONSET AND FAMILIAL PREDISPOSITION
MULTIPLE-SCLEROSIS SIBLING PAIRS - CLUSTERED ONSET AND FAMILIAL PREDISPOSITION
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DOI：
10.1212/wnl.40.10.1546
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发表时间：
1990-10-01
期刊：
影响因子：
9.9
通讯作者：
HAUSER, SL
中科院分区：
文献类型：
--
作者：
DOOLITTLE, TH;MYERS, RH;HAUSER, SL
我们评估了48复发缓解型多发性硬化症（R/R MS）同胞对来自44个家庭的年龄和MS症状的发病日期，临床过程和MS家族史。年龄和性别匹配的R/R MS临床患者提供了一个统计学比较组。发病年龄倾向于聚集在多重家庭。MS的初始症状发生在5岁以内的30/48对兄弟姐妹与16/48对照组相比。MS阳性家族史（兄弟姐妹除外）存在于43%的多重家族中，而单纯对照组为20%。在生活在危险年龄的一级、二级和三级亲属中，22/1，134的多重兄弟姐妹家庭成员可能或明确患有MS，而对照家庭成员为10/1，215。发病年龄聚集在兄弟姐妹一致的R/R MS和MS的风险增加，在其他家庭成员表明，影响疾病发作的因素可能是部分遗传在这些kinetics。
We evaluated 48 relapsing-remitting multiple sclerosis (R/R MS) sibling pairs derived from 44 families for age and date of onset of MS symptoms, clinical course, and family history of MS. Age- and sex-matched R/R MS clinic patients provided a statistical comparison group. The age of onset tended to cluster within multiplex families. The initial symptom of MS occurred within 5 years of age in 30/48 sibling pairs compared with 16/48 controls. A positive family history of MS (other than siblings) was present in 43% of the multiplex families compared with 20% among simplex controls. In 1st-, 2nd-, and 3rd-degree relatives who had lived into the age at risk, 22/1,134 family members of multiplex sibling pairs had probable or definite MS compared with 10/1,215 control family members. Age of onset clustering in siblings concordant for R/R MS and an increased risk of MS in other family members suggest that factors influencing disease onset may be in part inherited in these kindreds.