Effectiveness of Triptolide-Coated Stent on Decreasing Inflammation and Attenuation of Intimal Hyperplasia in a Pig After Coronary Angioplasty
Effectiveness of Triptolide-Coated Stent on Decreasing Inflammation and Attenuation of Intimal Hyperplasia in a Pig After Coronary Angioplasty
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DOI：
10.1177/0003319710385337
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发表时间：
2011-04-01
期刊：
影响因子：
2.8
通讯作者：
Jia, Dean
中科院分区：
文献类型：
--
作者：
Ge, HaiLong;Zhou, YuJie;Jia, Dean
目的：本研究旨在探讨雷公藤甲素涂层支架在抗炎、抑制内膜增生、预防再狭窄方面的作用。研究方法：在猪冠状动脉中共放置了15枚雷公藤甲素涂层支架（TCS）、12枚药物洗脱支架（DES）和12枚裸金属支架（BMS）。术后4周行冠状动脉造影、组织病理学检查及炎症标志物检测。结果如下：4周随访时，定量冠状动脉造影（QCA）显示TCS组和DES组的最小管腔直径大于BMS组，狭窄百分比和晚期管腔丢失小于BMS组。与BMS组相比，TCS组和DES组损伤和炎症评分均降低，新生内膜面积明显减少，管腔面积明显增大。结论：雷公藤甲素涂层支架通过抑制新生内膜增生和抗炎作用而发挥预防冠状动脉成形术后再狭窄的作用。
Objective: The study is to test the efficacy of triptolide-coated stent on anti-inflammatory and inhibiting intimal hyperplasia in preventing restenosis. Methods: A total of 15 triptolide-coated stents (TCSs), 12 drug-eluting stents (DESs), and 12 bare metal stents (BMSs) were deployed in porcine coronary arteries. Coronary angiography, histopathologic and inflammatory markers levels were analyzed at 4 week after stenting. Results: At 4-week follow-up, quantitative coronary angiography (QCA) showed that minimum lumen diameter was greater, and percentage stenosis and late lumen loss in TCS group and DES group were less than that of BMS group. Compared to BMS group, injury and inflammation score in TCS group and DES group were decreased, neointimal area significantly reduced and lumen area enlarged in TCS, DES group as well. Conclusion: Triptolide-coated stent showed the effect of preventing restenosis via inhibition of neointimal hyperplasia and anti-inflammation acts after coronary angioplasty.