The dorsal raphe nucleus - From silver stainings to a role in depression
The dorsal raphe nucleus - From silver stainings to a role in depression
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DOI：
10.1016/j.brainresrev.2007.01.002
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发表时间：
2007-10-01
影响因子：
--
通讯作者：
Steinbusch, Harry W. M.
中科院分区：
文献类型：
--
作者：
Michelsen, Kimmo A.;Schmitz, Christoph;Steinbusch, Harry W. M.
一百多年前，圣地亚哥拉蒙·卡哈尔（Ramon y Cajal）使用卡米洛·高尔基（Camillo Golgi）开发的一种新的染色方法，在许多其他结构中，我们今天称之为中缝背核（DRN）。多年来，DRN已成为一个多功能和多递质的核，调节或影响许多CNS过程。它是一个遗传学上古老的脑区，其投射延伸到CNS的大量区域和核团，特别是在前脑中。一些与DRN相关的发现与神经科学史上的重要事件密切相关，例如新组织学方法的发明，新神经递质系统的发现以及神经递质功能与情绪障碍之间的联系。目前对DRN的广泛兴趣的主要原因之一是该核参与抑郁症。这种参与特别归因于DRN的主要递质血清素。本文从历史的角度出发，描述了DRN的形态、上行投射和多递质性质，并强调了其作为抑郁症研究的关键靶点的作用。(C)2007 Elsevier B.V.保留所有权利。
Over a hundred years ago, Santiago Ramon y Cajal used a new staining method developed by Camillo Golgi to visualize, among many other structures, what we today call the dorsal raphe nucleus (DRN) of the midbrain. Over the years, the DRN has emerged as a multifunctional and multitransmitter nucleus, which modulates or influences many CNS processes. It is a phylogenetically old brain area, whose projections reach out to a large number of regions and nuclei of the CNS, particularly in the forebrain. Several DRN-related discoveries are tightly connected with important events in the history of neuroscience, for example the invention of new histological methods, the discovery of new neurotransmitter systems and the link between neurotransmitter function and mood disorders. One of the main reasons for the wide current interest in the DRN is the nucleus' involvement in depression. This involvement is particularly attributable to the main transmitter of the DRN, serotonin. Starting with a historical perspective, this essay describes the morphology, ascending projections and multitransmitter nature of the DRN, and stresses its role as a key target for depression research. (C) 2007 Elsevier B.V. All rights reserved.