Effects of the cannabinoid receptor agonist CP 55,940 and the cannabinoid receptor antagonist SR 141716 on intracranial self-stimulation in Lewis rats
Effects of the cannabinoid receptor agonist CP 55,940 and the cannabinoid receptor antagonist SR 141716 on intracranial self-stimulation in Lewis rats
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DOI：
10.1016/s0024-3205(01)01366-2
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发表时间：
2001-11-21
期刊：
影响因子：
6.1
通讯作者：
McGregor, LS
中科院分区：
文献类型：
--
作者：
Arnold, JC;Hunt, GE;McGregor, LS
刘易斯大鼠进行训练，自我刺激内侧前脑束（MFB）使用率-频率范例。然后测试大麻素受体激动剂CP 55，940、选择性大麻素受体拮抗剂SR 141716和多巴胺D-1受体拮抗剂SCH 23390的作用。CP 55，940（0、10、25和50 μ g/kg i.p.）对MFB自我刺激行为没有影响，如M-50所评估的，M-50是获得半最大反应率的刺激频率。对于SR 141716，仅极高剂量（20 mg/kg i. p.）对刺激的奖赏效应产生了显著的抑制作用。这被认为是M-50的增加。SR 141716的所有其他剂量（0、1、3、10 mg/kg i. p.）对M-50的调节无效相比之下，相对低剂量（0.06mg/kg i. p.）SCH 23390引起M-50大幅增加。这些结果表明，相对温和的影响，如果有的话，外源性或内源性大麻素奖励相关的神经传递。(C)2001 Elsevier Science Inc. All rights reserved.
Lewis rats were trained to self-stimulate the medial forebrain bundle (MFB) using a rate-frequency paradigm. They were then tested for the effects of the cannabinoid receptor agonist CP 55,940, the selective cannabinoid receptor antagonist SR 141716 and the dopamine D-1 receptor antagonist SCH 23390. CP 55,940 (0, 10, 25 and 50 mug/kg i.p.) had no effect on MFB self-stimulation behaviour as assessed by the M-50, the stimulation frequency at which half-maximal response rates were obtained. With SR 141716, only a very high dose (20 mg/kg i.p.) caused a significant inhibition of the rewarding efficacy of the stimulation. This was seen as an increase in the M-50. All other doses of SR 141716 (0, 1, 3, 10 mg/kg i.p.) were ineffective in modulating the M-50. By comparison, a relatively low dose (0.06 mg/kg i.p.) of SCH 23390 caused a large increase in M-50. These results indicate a relatively modest influence, if any at all, of exogenous or endogenous cannabinoids on reward-relevant neurotransmission. (C) 2001 Elsevier Science Inc. All rights reserved.