Lymph node density in papillary thyroid carcinoma is a prognostic factor after adjusting for pathological stage.
Lymph node density in papillary thyroid carcinoma is a prognostic factor after adjusting for pathological stage.
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DOI：
10.18632/oncotarget.25453
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发表时间：
2018-06-01
期刊：
影响因子：
--
通讯作者：
Hasegawa Y
中科院分区：
文献类型：
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作者：
Suzuki H;Koide Y;Hanai N;Nishikawa D;Beppu S;Mikami S;Hasegawa Y
我们调查了分化型乳头状甲状腺癌的淋巴结密度和生存结果之间的可能联系，并在第八版国际癌症控制联盟肿瘤-淋巴结转移分类恶性肿瘤的多因素分析中检验了淋巴结密度是否是根据病理分期调整的预测因子。共纳入543例甲状腺乳头状癌患者。我们根据第八版进行了重新分级。淋巴结密度为阳性淋巴结数与切除淋巴结总数之比。第八版对病理分期进行调整后的单因素分析采用对数等级检验，多因素分析采用COX比例风险模型。在对15 0例pN1bM0患者进行的单变量和多变量分析中，淋巴结密度为≥0.3和pN1b的患者显著地与疾病特异性生存期缩短有关。在对所有543名患者进行的单变量和多变量分析中，带有pN1b的≥为0.3时的淋巴结密度也与较短的总生存期和疾病特异性生存期显著相关。综上所述，这些结果提示第八版中的淋巴结密度可以作为一个预测预后的指标，在对病理分期进行调整后。
We investigated the possible association between the lymph node density and survival outcomes in differentiated papillary thyroid carcinoma, and examined whether the lymph node density was a predictor in a multivariate analysis adjusted for the pathological stage in the eighth edition of the Union for International Cancer Control Tumor-Node Metastasis Classification of Malignant Tumors. A total of 543 patients with papillary thyroid carcinoma were enrolled. We performed restaging according to the eighth edition. The lymph node density was the ratio between number of positive lymph nodes and total number of excised lymph nodes. A log-rank test and Cox's proportional hazards model were used for univariate and multivariate analysis with adjustment for the pathological stage in the eighth edition, respectively. In both the univariate and multivariate analyses of 150 patients with pN1bM0, the presence of a lymph node density of ≥ 0.3 with pN1b was significantly associated with shorter disease-specific survival. In both the univariate and multivariate analyses of all 543 patients, a lymph node density of ≥ 0.3 with pN1b were also significantly associated with shorter overall and disease-specific survival. In conclusion, these results suggest that the lymph node density can be used as a predictor for the survival outcomes after adjustment for the pathological stage in the eighth edition.