Stress exposures, neurodevelopment and health measures in the ABCD study
Stress exposures, neurodevelopment and health measures in the ABCD study
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DOI：
10.1016/j.ynstr.2019.100157
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发表时间：
2019-02-01
影响因子：
5
通讯作者：
Dowling, Gayathri J.
中科院分区：
文献类型：
--
作者：
Hoffman, Elizabeth A.;Clark, Duncan B.;Dowling, Gayathri J.
青少年大脑认知发展（ABCD）研究是一项关于大脑发育和儿童健康的大型纵向研究，其独特的定位是探索压力、神经发育和精神症状之间的关系，包括物质使用和成瘾。关于不良经历如何影响发育中的大脑以及认知、社交、情感和学业成绩，我们还有很多不知道的地方。ABCD研究收集的数据将允许检查青春期这些变量之间的关系，包括压力源（例如，虐待，忽视，家庭挑战，父母物质使用）对心理适应和其他压力反应的影响。一份包括身心健康、物质使用、文化和环境、神经认知评估、生物标本分析以及结构和功能神经成像在内的综合协议，将为了解青少年发展背景下压力源对健康和其他结果的影响提供机会。这一知识可能会导致干预措施的发展，减少甚至逆转压力源的影响。
The Adolescent Brain Cognitive Development (ABCD) Study, a large, longitudinal study of brain development and child health, is uniquely positioned to explore relationships among stress, neurodevelopment, and psychiatric symptomatology, including substance use and addiction. There is much we do not know about how adverse experiences affect the developing brain and cognitive, social, emotional, and academic outcomes. The data collected by the ABCD Study will allow the examination of the relationships among these variables in adolescence, including the effects of stressors (e.g., abuse, neglect, household challenges, parental substance use) on psychological adjustment and other stress responses. A comprehensive protocol that includes physical and mental health, substance use, culture and environment, neurocognitive assessments, biospecimen analyses, and structural and functional neuroimaging will provide opportunities for learning about the impacts of stressors on health and other outcomes in the context of adolescent development. This knowledge could lead to the development of interventions that reduce or even reverse the impacts of stressors.