Computational Fluid Simulation of Fibrinogen around Dental Implant Surfaces
Computational Fluid Simulation of Fibrinogen around Dental Implant Surfaces
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DOI：
10.3390/ijms21020660
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发表时间：
2020-01-02
影响因子：
5.6
通讯作者：
Ogawa, Takahiro
中科院分区：
文献类型：
--
作者：
Kitajima, Hiroaki;Hirota, Makoto;Ogawa, Takahiro
钛种植体的紫外线处理使其表面亲水并增强骨整合。然而，该机制尚未完全理解。本研究假设纤维蛋白原（血凝块形成和伤口愈合的关键分子）的募集受植入物表面亲水性/疏水性程度的影响。创建计算流体动力学（CFD）植入物模型，用于流体流动模拟。亲水性水平由植入物表面与血浆之间的接触角表示，范围为5度（超亲水性）、30度（亲水性）至50度和70度（疏水性）以及100度（疏水性）。流入植入物界面区的纤维蛋白原质量（纤维蛋白原浸润）以时间依赖性方式增加，亲水性更强的表面斜率更陡。亲水性表面也促进了血浆吸收到界面区（血浆渗透）中的质量，但它是快速的且非时间依赖性的。纤维蛋白原浸润率与血浆浸润率无线性相关性。这些结果表明，亲水性植入物表面促进纤维蛋白原和血浆浸润到它们的界面。然而，两种组分的浸润不成比例，这意味着亲水性植入物表面选择性增强纤维蛋白原的募集。
Ultraviolet treatment of titanium implants makes their surfaces hydrophilic and enhances osseointegration. However, the mechanism is not fully understood. This study hypothesizes that the recruitment of fibrinogen, a critical molecule for blood clot formation and wound healing, is influenced by the degrees of hydrophilicity/hydrophobicity of the implant surfaces. Computational fluid dynamics (CFD) implant models were created for fluid flow simulation. The hydrophilicity level was expressed by the contact angle between the implant surface and blood plasma, ranging from 5 degrees (superhydrophilic), 30 degrees (hydrophilic) to 50 degrees and 70 degrees (hydrophobic), and 100 degrees (hydrorepellent). The mass of fibrinogen flowing into the implant interfacial zone (fibrinogen infiltration) increased in a time dependent manner, with a steeper slope for surfaces with greater hydrophilicity. The mass of blood plasma absorbed into the interfacial zone (blood plasma infiltration) was also promoted by the hydrophilic surfaces but it was rapid and non-time-dependent. There was no linear correlation between the fibrinogen infiltration rate and the blood plasma infiltration rate. These results suggest that hydrophilic implant surfaces promote both fibrinogen and blood plasma infiltration to their interface. However, the infiltration of the two components were not proportional, implying a selectively enhanced recruitment of fibrinogen by hydrophilic implant surfaces.