Evolution of genes and genomes on the Drosophila phylogeny
Evolution of genes and genomes on the Drosophila phylogeny
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DOI：
10.1038/nature06341
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发表时间：
2007-11-08
期刊：
影响因子：
64.8
通讯作者：
MacCallum, Iain
中科院分区：
文献类型：
--
作者：
Clark, Andrew G.;Eisen, Michael B.;MacCallum, Iain
在系统发育框架中对多个基因组进行比较分析，大大提高了进化推断的精度和灵敏度，产生了比单基因组分析更可靠的结果。12个果蝇物种的基因组，其中10个是第一次在这里（sechellia，simulans，yakuba，erecta，ananassae，persimilis，willistoni，mojavensis，virilis和grimshawi），说明如何率和模式的序列差异分类群可以照亮进化过程中的基因组规模。这些基因组序列增强了使黑腹果蝇成为动物遗传学杰出模型的强大遗传工具，并将进一步促进对发育机制、细胞生物学、遗传学、疾病、神经生物学、行为、生理学和进化的基础研究。尽管这些果蝇物种之间有显着的相似之处，我们发现许多puperminal非中性的蛋白质编码基因，非编码RNA基因，顺式调控区的变化。这些可能证明是这些不同物种生态和行为差异的基础。
Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.