Meticillin-resistant Staphylococcus aureus CC398 is an increasing cause of disease in people with no livestock contact in Denmark, 1999 to 2011.
Meticillin-resistant Staphylococcus aureus CC398 is an increasing cause of disease in people with no livestock contact in Denmark, 1999 to 2011.
复制标题
在1999年至2011年，丹麦无牲畜接触的患者中，抗甲基肽的金黄色葡萄球菌CC398是疾病的越来越多的原因。
DOI：
10.2807/1560-7917.es.2015.20.37.30021
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Skov RL
中科院分区：
文献类型：
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作者：
Larsen J;Petersen A;Sørum M;Stegger M;van Alphen L;Valentiner-Branth P;Knudsen LK;Larsen LS;Feingold B;Price LB;Andersen PS;Larsen AR;Skov RL
家畜构成了耐甲氧西林金黄色葡萄球菌分离株的潜在储存库，属于克隆复合体398(MRSA CC398-IIa)中最近衍生的谱系。自21世纪初被发现以来，这种血统已成为欧洲人类疾病的主要原因，对畜牧业集约化生产的国家构成了严重的公共卫生挑战。为了追溯丹麦人类殖民和感染MRSA CC398-IIa的历史，我们对1999年至2011年收集的MRSA分离株进行了全国性的回顾性研究。在筛选的7,429株MRSA中，我们鉴定出416株MRSA CC398-IIa。在这些病例中，148例来自感染者，其中51例来自报告没有接触牲畜的患者。丹麦首批MRSA CC398-IIa感染病例发生在2004年。随后，从2004年到2011年，MRSA CC398-IIa感染的发病率呈66%的线性年增长(从每10万人年0.09人增加到1.1人)。MRSA CC398-IIa感染患者与家畜接触者之间存在明显的时间和空间关系。这些发现表明，MRSA CC398-IIa从畜牧业或畜牧业工人大量传播到丹麦社区，并强调需要制定战略，控制其在农场内外的传播。
Livestock constitutes a potential reservoir of meticillin-resistant Staphylococcus aureus isolates belonging to a recently derived lineage within clonal complex 398 (MRSA CC398-IIa). Since its discovery in the early 2000s, this lineage has become a major cause of human disease in Europe, posing a serious public health challenge in countries with intensive livestock production. To retrace the history of human colonisation and infection with MRSA CC398-IIa in Denmark, we conducted a nationwide, retrospective study of MRSA isolates collected from 1999 to 2011. Among 7,429 MRSA isolates screened, we identified 416 MRSA CC398-IIa isolates. Of these, 148 were from people with infections, including 51 from patients reporting no livestock exposure. The first cases of MRSA CC398-IIa infection in Denmark occurred in 2004. Subsequently, the incidence of MRSA CC398-IIa infection showed a linear annual increase of 66% from 2004 to 2011 (from 0.09 to 1.1 per 100,000 person-years). There were clear temporal and spatial relationships between MRSA CC398-IIa-infected patients with and without livestock exposure. These findings suggest substantial dissemination of MRSA CC398-IIa from livestock or livestock workers into the Danish community and underscore the need for strategies to control its spread both on and off the farm.