Pregnancy hormones, pre-eclampsia, and implications for breast cancer risk in the offspring.
Pregnancy hormones, pre-eclampsia, and implications for breast cancer risk in the offspring.
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发表时间：
2003-07
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通讯作者：
R. Tamimi;P. Lagiou;L. Vatten;L. Mucci;D. Trichopoulos;S. Hellerstein;A. Ekbom;H. Adami;C. Hsieh
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作者：
R. Tamimi;P. Lagiou;L. Vatten;L. Mucci;D. Trichopoulos;S. Hellerstein;A. Ekbom;H. Adami;C. Hsieh
本研究的目的是前瞻性地评估妊娠激素水平作为先兆子痫的后续发展的相关性，先兆子痫是一种已被证明与后代患乳腺癌风险呈负相关的疾病。在马萨诸塞州的波士顿，对260名白人妇女进行了妊娠期随访。在妊娠第16周和第27周采集母体血液，18名妇女在采血后被诊断为先兆子痫。社会人口学变量和先兆子痫的危险因素的信息通过访谈者管理的问卷调查和病历审查收集。在第16周，孕酮水平与先兆子痫之间存在非显著性正相关[相对危险度（RR）= 1.63，95%置信区间（CI），0.97-2.74，每增加1 SD]。到第27周，孕酮和先兆子痫之间的关联加强（RR = 2.65，95%CI，1.46-4.81，每SD），性激素结合球蛋白水平与先兆子痫有点负相关（RR = 0.61，95%CI，0.31-1.20，每SD）。催乳素、雌二醇和雌三醇水平无差异。我们的研究结果表明，孕激素可能在子痫前期病理的晚期表现中发挥作用，但也与孕激素增加代表早期代偿机制的假设相一致。
The aim of this study is to prospectively assess pregnancy hormone levels as correlates of subsequent development of pre-eclampsia, a condition that has been shown to be inversely associated with breast cancer risk in the offspring. A cohort of 260 Caucasian women in Boston, Massachusetts, was followed through pregnancy. Maternal blood was collected at the 16th and 27th weeks of gestation, and 18 women were diagnosed with pre-eclampsia after blood collection. Information on sociodemographic variables and risk factors of pre-eclampsia was collected through an interviewer-administered questionnaire and review of medical records. At the 16th week, there was a nonsignificant positive association between progesterone levels and pre-eclampsia [relative risk (RR) = 1.63, 95% confidence interval (CI), 0.97-2.74, per 1 SD increase]. By the 27th week, the association between progesterone and pre-eclampsia was strengthened (RR = 2.65, 95% CI, 1.46-4.81, per SD), and sex hormone-binding globulin levels were somewhat inversely related to pre-eclampsia (RR = 0.61, 95% CI, 0.31-1.20, per SD). No difference was found with respect to prolactin, estradiol, and estriol levels. Our findings indicate that progesterone may have a role in the late manifestation of pre-eclampsia pathology but are also compatible with the hypothesis that increases in progesterone represent an early compensatory mechanism.