Gut inflammation in response to injury: potential target for therapeutic intervention.
Gut inflammation in response to injury: potential target for therapeutic intervention.
复制标题
DOI：
10.2174/157489111796887837
复制
发表时间：
2011-09
影响因子：
--
通讯作者：
S. Akhtar;M. Choudhry
中科院分区：
文献类型：
--
作者：
S. Akhtar;M. Choudhry
创伤性损伤是全世界关注的一个重大公共卫生问题。肠道和/或其衍生因子在损伤相关的发病机制中的作用已被提出。损伤引起各种信号传导途径的激活，沿着肠中促炎细胞因子、趋化因子和粘附分子的释放和激活。这介导了中性粒细胞向肠道的渗透。致敏和随后活化的中性粒细胞释放各种蛋白水解酶和超氧阴离子，其最终导致肠道炎症和/或损伤。本文将讨论各种因素导致肠道炎症损伤后。本文还讨论了一些与肠道炎症相关的专利。
Traumatic injuries present a major public health concern worldwide. A role of gut and/or its derived factors has been suggested in the pathogenesis associated with injury. Injury causes the activation of various signaling pathways along with the release and activation of pro-inflammatory cytokines, chemokines and adhesion molecules in the intestine. This mediates infiltration of neutrophils into the intestine. Primed and subsequently activated neutrophils release various proteolytic enzymes and superoxide anion which ultimately result in intestinal inflammation and/or injury. This review will discuss the various factors contributing to intestinal inflammation following injury. Some of the patents relevant to intestinal inflammation have also been discussed in the present manuscript.