The pattern of gastroesophageal reflux in asthmatic children
The pattern of gastroesophageal reflux in asthmatic children
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DOI：
10.1081/jas-120002194
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发表时间：
2002-01-01
影响因子：
1.9
通讯作者：
Zoppi, G
中科院分区：
文献类型：
--
作者：
Cinquetti, M;Micelli, S;Zoppi, G
胃食管反流（GER）与哮喘之间的联系并非偶然。本研究的目的是对一组哮喘儿童进行24小时胃食管pH监测，并将结果与患者的病史和临床资料联系起来。我们研究了77名年龄在39至170个月之间患有复发性和/或治疗抵抗性哮喘的儿童。收集每位患者的病史资料，包括：呼吸道症状的严重程度和特征；存在过敏（如有）；有胃炎相关症状（如有）；以及是否有食管炎相关症状。通过24小时计算机监测所有患者的主要指标来测量食管pH值。47名儿童也接受了胃食管内窥镜检查。根据反流指数，GER的患病率为61%（截止值为4.2%）。这些哮喘儿童的胃食管反流主要表现为短暂的日间发作。患者倾向于出现GER，主要伴有呕吐，而不伴有食管炎的体征和症状。反流发作持续时间短，表明食管清除率良好。呼吸道症状的发作时间（白天/晚上）与任何特定类型的GER无关，GER的严重程度往往与哮喘的严重程度成正比。没有发现GER与过敏之间的相关性。病理性和非病理性GER患者的临床或病史结果无统计学差异。
The association between gastroesophageal reflux (GER) and asthma is not fortuitous. The objective of our study was to test a group of children with asthma by 24 hr gastroesophageal pH monitoring and to relate the results to the patients' medical history and clinical data. We studied 77 children aged from 39 to 170 months suffering from particularly recurrent and/or therapy-resistant asthma. Medical history data were collected for each patient and included: severity and characteristics of respiratory symptoms; presence, if any, of allergy; presence, if any, of GER-related symptoms; and presence, if any, of esophagitis-related symptoms. Esophageal pH was measured by 24 hr computerized monitoring of the main measures in all patients. Forty-seven children were also examined by, gastroesophageal endoscopy. The prevalence of GER was 61% on the basis of the reflux index (cutoff: 4.2%). Gastroesophageal reflux in these asthmatic children was characterized mainly by short-lasting daytime episodes. The patients tended to present GER mainly associated with vomiting but not with signs and symptoms of esophagitis. The short-lasting nature of the reflux episodes demonstrates good esophageal clearance. The time of onset of respiratory symptoms (day/night) was not associated with any particular type of GER, the severity of which tends to be proportional to the seriousness of the asthma. No correlation was,found between GER and allergy. No statistically significant differences were found in clinical or medical history findings between patients with pathologic and nonpathologic GER.