Relationship of psychiatric diagnosis and weight loss maintenance in obese breast cancer survivors.
Relationship of psychiatric diagnosis and weight loss maintenance in obese breast cancer survivors.
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DOI：
10.1038/oby.2003.185
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发表时间：
2003-11
期刊：
影响因子：
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通讯作者：
Isabella Jenkins;Z. Djuric;L. Darga;Nora M Dilaura;M. Magnan;W. Hryniuk
中科院分区：
文献类型：
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作者：
Isabella Jenkins;Z. Djuric;L. Darga;Nora M Dilaura;M. Magnan;W. Hryniuk
目的：肥胖的乳腺癌幸存者是一个独特的减肥咨询人群，因为肥胖和乳腺癌的诊断都会增加抑郁的风险。在这项先导性研究中，研究对象为肥胖的乳腺癌幸存者，研究对象为与精神疾病诊断相关的体重减轻维持情况。研究方法和程序：48名受试者。这项干预使用了个性化的饮食和锻炼咨询，持续了24个月。结果：9名在12个月前退出研究的受试者均未能完成结构化的精神病学访谈。在剩下的39名受试者中，9名患有严重的抑郁障碍，10名患有严重程度较轻的精神障碍，如适应障碍。在12个月的时间点上，有任何精神疾病诊断的受试者的体重下降明显低于没有诊断的受试者(分别为6.3%和12.6%的基线体重下降)。在30个月的随访中，患有任何精神障碍的受试者平均体重下降了基线体重的1.2%，而没有诊断的受试者的体重下降了7.8%。讨论：这些结果表明，精神障碍的存在可能会干扰体重减轻。因此，对精神障碍的认识和治疗在减肥的尝试中可能很重要，这在癌症幸存者等人群中尤其重要，他们似乎比普通人群有更高的抑郁症和其他障碍的发生率。
Objective: Obese breast cancer survivors are a unique population for weight loss counseling because both obesity and a diagnosis of breast cancer can increase the risk of depression. In this pilot study, weight loss maintenance was examined in obese breast cancer survivors with relationship to psychiatric diagnosis.Research Methods and Procedures: Forty‐eight subjects were enrolled. The intervention, which used individualized counseling for diet and exercise, lasted 24 months. After a 6‐month period of no contact with study subjects, a follow‐up body weight was obtained at 30 months.Results: The nine subjects who dropped out of the study before 12 months all failed to complete a structured psychiatric interview. Of the remaining 39 subjects, 9 had major depressive disorder, and 10 had a definable psychiatric disorder of lesser severity such as adjustment disorder. Subjects with any type of psychiatric diagnosis displayed significantly less weight loss at the 12‐month time‐point than those with no diagnosis (6.3% vs. 12.6% loss of baseline weight, respectively). At the 30‐month follow‐up visit, subjects with any psychiatric disorder had a mean weight loss of 1.2% of baseline weight compared with 7.8% weight loss in subjects with no diagnosis.Discussion: These results suggest that the presence of psychiatric disorders can interfere with weight loss. Therefore, recognition and treatment of psychiatric disorders may be important in attempts at weight reduction, and this will be especially important in populations such as cancer survivors, who seem to have higher rates of depression and other disorders than the general population.