The Comparative Diagnostic Features of Canine and Human Lymphoma.
The Comparative Diagnostic Features of Canine and Human Lymphoma.
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DOI：
10.3390/vetsci3020011
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发表时间：
2016-06-01
影响因子：
2.4
通讯作者：
Linden, Michael A
中科院分区：
文献类型：
--
作者：
Seelig, Davis M;Avery, Anne C;Linden, Michael A
非霍奇金淋巴瘤（NHL）是一个异质性的淋巴恶性肿瘤家族，是犬和人类最常见的肿瘤之一。由于共同的分子，信号，发病率和病理特征，有一个强大的框架支持利用犬淋巴瘤作为比较，大型动物模型的人NHL。与生物学相似性一致，目前对犬淋巴瘤的诊断和分类方法是基于人类世界卫生组织指南。虽然这种方法有助于提高犬淋巴瘤的潜在生物学范围的认识，但也很明显，最合适的诊断理念必须是多模式的，即在建立最终疾病诊断之前需要了解显微镜，免疫表型和临床特征。本文旨在通过介绍其最常见形式的显微镜和免疫表型特征来说明犬淋巴瘤诊断的比较相似性和差异性。
The non-Hodgkin lymphomas (NHLs) are a heterogeneous family of lymphoid malignancies that are among the most common neoplasms of both dogs and humans. Owing to shared molecular, signaling, incidence, and pathologic features, there is a strong framework supporting the utilization of canine lymphoma as a comparative, large animal model of human NHL. In alignment with the biologic similarities, the current approach towards the diagnosis and classification of canine lymphoma is based upon the human World Health Organization guidelines. While this approach has contributed to an increasing appreciation of the potential biological scope of canine lymphoma, it has also become apparent that the most appropriate diagnostic philosophy must be multimodal, namely by requiring knowledge of microscopic, immunophenotypic, and clinical features before establishing a final disease diagnosis. This review seeks to illustrate the comparative similarities and differences in the diagnosis of canine lymphoma through the presentation of the microscopic and immunophenotypic features of its most common forms.