A Novel Analysis of CMAP Scans From Perspective of Information Theory: CMAP Distribution Index (CDIX)
A Novel Analysis of CMAP Scans From Perspective of Information Theory: CMAP Distribution Index (CDIX)
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DOI：
10.1109/tbme.2022.3212312
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发表时间：
2023-04-01
影响因子：
4.6
通讯作者：
Zhou, Ping
中科院分区：
文献类型：
--
作者：
Lu, Zhiyuan;Chen, Maoqi;Zhou, Ping
目的：复合肌肉动作电位（CMAP）扫描是一种检查神经肌肉疾病的有效方法。本研究的目的是从信息论的角度发展一种新的分析CMAP扫描。研究方法：提出了一种基于信息熵计算的CMAP分布指数（CDIX）来表征CMAP扫描。使用健康对照和脊髓损伤（SCI）受试者的CMAP扫描数据评估CDIX的性能，并与D50和MscanFit运动单位数估计（MUNE）进行比较。结果：脊髓损伤患者的CDIX明显低于健康对照组（p < 0.001）。在CDIX和MscanFit MUNE之间发现显著相关性（R-2 = 0.58，p < 0.001）。在所有测试参数（最大CMAP、D50、MscanFit MUNE和CDIX）中，CDIX在SCI和健康对照受试者之间实现了重叠区的最小相对宽度（WOZ%）。结论：CDIX可作为反映运动单位丧失和肌纤维神经再支配变化的一个有用指标。
Objective: The compound muscle action potential (CMAP) scan is a useful technique for examination of neuromuscular disorders. The objective of this study is to develop a novel analysis of CMAP scans from the perspective of information theory. Methods: A novel index parameter called CMAP distribution index (CDIX) was developed to characterize CMAP scan based on calculation of the information entropy. The performance of CDIX was evaluated using CMAP scan data from healthy control and spinal cord injury (SCI) subjects, and compared with D50 and MScanFit motor unit number estimation (MUNE). Results: CDIX was significantly lower for the SCI subjects compared with the healthy control subjects (p < 0.001). A significant correlation (R-2 = 0.58, p < 0.001) was found between CDIX and MScanFit MUNE. Among all tested parameters (maximum CMAP, D50, MScanFit MUNE and CDIX), CDIX achieved the smallest relative width of the overlapping zone (WOZ%) between SCI and healthy control subjects. Conclusion: CDIX can be inferred as a useful index reflecting motor unit loss and muscle fiber reinnervation changes.