Molecular biological definition of the prothymocyte: problems of commitment and lineage promiscuity.
Molecular biological definition of the prothymocyte: problems of commitment and lineage promiscuity.
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原胸腺细胞的分子生物学定义：承诺和谱系混杂的问题。
DOI：
10.1007/bf02935518
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发表时间：
1987
影响因子：
4.4
通讯作者：
Yuille,MA
中科院分区：
文献类型：
--
作者：
Silverstone,AE;Yuille,MA
本系列中关于前胸腺细胞的最后一个小对称[1]和随后的总结[2]出现在T细胞个体发育所有阶段的细胞和分子生物学方法爆炸性增长的开始。然而，尽管有这些进展，我们和我们的同事谁写的论文，都同意不仅T细胞个体发育的最早阶段的主要问题仍然没有解决，而且问题的复杂性随着信息的增加而增加。最终，这必将使我们对前T细胞和早期T细胞的发育有更深入的了解。首先，重申“原胸腺细胞”的原始概念是恰当的。据推测，这是一种胸腺外细胞（与胸腺内细胞类型不同），目前尚不清楚其是否具有胸腺内细胞的表面标志物，但它可以在受辐射的胸腺中重新增殖。据推测，在胚胎发育期间，它也在胸腺的初级发育中发挥了这种功能[1-3]。这一点的一个重要推论是，同一个细胞致力于成为T细胞，而不是
The last minisymposium in this series on the topic of the prothymocyte [1] and the subsequent summary [2] came at the beginning of a time of explosive growth in cell and molecular biological approaches to all stages of T cell ontogeny. However, despite these advances, we, and our colleagues who have written the papers herewith, would all agree not only that the major questions of the earliest stages of T cell ontogeny remain unresolved, but also that the complexity of the questions has increased alongside the information. Ultimately this will surely lead to greater understanding of pre-T and early T cell development.It is appropriate, first, to restate the original concept of the'prothymocyte'. This supposedly was an extrathymic cell (as distinguished from an intrathymic cell type) which was not known to bear surface markers characteristic of cells within the thymus but which could repopulate an irradiated thymus. It presumably also fulfilled such a function in the primary development of the thymus during embryogenesis [1-3]. An important corollary of this was that the same cell was committed to becoming a T cell, and not