Heritability of binge-eating and broadly defined bulimia nervosa
Heritability of binge-eating and broadly defined bulimia nervosa
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DOI：
10.1016/s0006-3223(98)00280-7
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发表时间：
1998-12-15
影响因子：
10.6
通讯作者：
Kendler, KS
中科院分区：
文献类型：
--
作者：
Bulik, CM;Sullivan, PF;Kendler, KS
背景资料：使用在两个不同时间获得的诊断信息，我们将测量误差纳入结构方程双模型，以评估加性遗传、共同环境和个体特异性环境因素对暴食和广义贪食症（BN）易感性的贡献。我们还评估了平等环境假设（EEA）在这两种表型中的有效性。方法：我们访问了1897对女性双胞胎（包括854对双胞胎中的两个成员）从基于人口的登记册中获得关于他们的暴食和广义BN的两次（大约间隔5年）的一生历史。暴食（kappa = 0.34）和广义BN（kappa = 0.28）的可靠性较低。基于单次访谈，暴食的遗传率估计为50%，广义BN为60%，其余的方差归因于个人特定的环境。共同的环境影响没有影响的责任，无论是性状。通过结合两个访谈波的信息，从而将测量误差纳入结构方程模型，估计的潜在脆弱性暴饮暴食（82%）和广义BN（83%）的遗传性大幅增加。虽然没有违反EEA检测暴食，共社会化影响双胞胎一致性广泛定义的BN.Conclusions：暴食和广泛定义的BN的一生的历史似乎是高度遗传的条件下的低可靠性。生物精神病学1998;44：1210-1218. (C)1998年生物精神病学学会。
Background: Using diagnostic information obtained at two different times, we incorporated error of measurement into structural equation twin models to evaluate the contribution of additive genetic, common environmental, and individual-specific environmental factors to the liability to binge-eating and broadly defined bulimia nervosa (BN). We also evaluated the validity of the equal environment assumption (EEA) with reference to these two phenotypes.Methods: We interviewed 1897 female twins (including both members of 854 twin pairs) from a population-based register about their lifetime history of binge-eating and of broadly defined BN twice, approximately 5 years apart.Results: The reliabilities of a lifetime history of binge-eating (kappa = .34) and of broadly defined BN (kappa = .28) were low. Based on single interviews, the heritability of binge-eating was estimated to be 50% and broad BN 60%, with the remaining variance attributable to individual-specific environment. Common environmental influences had no effect on liability to either trait. By combining information from two interview waves and thereby incorporating error of measurement into a structural equation model, the estimated heritability of the latent vulnerability to binge-eating (82%) and broadly defined BN (83%) increased substantially. Although there were no violations of the EEA detected for binge-eating, cosocialization influenced twin concordance for broadly defined BN.Conclusions: Lifetime histories of binge-eating and broadly defined BN appear to be highly heritable conditions of low reliability. Biol Psychiatry 1998;44:1210-1218. (C) 1998 Society of Biological Psychiatry.