HIV prevalence and phylogenetic characteristics among entry travelers in Xishuangbanna prefecture, Yunnan province, between 2003 and 2012
HIV prevalence and phylogenetic characteristics among entry travelers in Xishuangbanna prefecture, Yunnan province, between 2003 and 2012
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2003-2012年云南省西双版纳地区入境旅客HIV感染情况及系统发育特征
DOI：
10.1002/jmv.24740
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发表时间：
2017-06-01
影响因子：
12.7
通讯作者：
Xia, Xueshan
中科院分区：
文献类型：
--
作者：
Wang, Binghui;Liang, Yuebo;Xia, Xueshan
西双版纳是云南省南部的一个热门旅游目的地，与越南、老挝和缅甸接壤。每年有200多万跨境旅客通过大罗和磨憨两个陆路口岸进入中国。为明确入境人员HIV-1流行特征，采用回顾性流行病学调查方法。2003 - 2012年，91432名入境旅客中检出HIV-1阳性196人，感染率为0.21%。获得81个gag-pol基因序列用于系统发育分析和随后的重组分析。结果表明，该人群中最流行的HIV-1亚型是循环重组型（CRF）01_AE（42，51.86%），其次是CRF08_BC CRF 07_BC（4，4.94%），B'（2，2.47%），C（2，2.47%），其它重组体（9，11.11%）和未定义亚型（5，6.17%）。两口岸入境人员HIV-1基因型分布不同，大罗口岸入境人员CRF01_AE和CRF08_BC基因型比例较高，磨憨口岸入境人员C亚型和URF基因型比例较高。未定义的亚型表明出现了新的HIV-1亚型或CRF。这一发现有助于制定艾滋病预防策略。
Xishuangbanna is a popular tourist destination in southern Yunnan Province, bordering with Vietnam and Laos, and Myanmar. There are more than 2 million cross-border travelers annually entering China at two land ports, Daluo and Mohan. To clarify the characteristics of HIV-1 prevalence among entry travelers, a retrospective epidemic investigation was conducted. Between 2003 and 2012, 196 among 91432 entry travelers were detected to be HIV-1-positive, accounting for infection rate of 0.21%. Eighty-one gag-pol gene sequences were obtained for phylogenetic analyses and subsequent recombination analysis. It was shown that the most prevalent HIV-1 subtype in this population was circulating recombinant form (CRF) 01_AE (42, 51.86%), followed by CRF08_BC (17, 20.99%), CRF07_BC (4, 4.94%), B' (2, 2.47%), C (2, 2.47%), other recombinants (9, 11.11%), and undefined subtype (5, 6.17%). HIV-1 genotype distribution among travelers entering at two land ports is different, CRF01_AE and CRF08_BC accounted for a larger percentage among individuals from Daluo, whereas the proportions of subtype C and undefined URFs were larger among individuals from Mohan. The undefined subtype indicates the occurrence of novel HIV-1 subtype or CRF. This finding is useful for developing of AIDS prevention strategies.