Gut microbiota dysbiosis contributes to the development of hypertension.
Gut microbiota dysbiosis contributes to the development of hypertension.
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肠道菌群失调导致高血压的发生
DOI：
10.1186/s40168-016-0222-x
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发表时间：
2017-02-01
期刊：
影响因子：
15.5
通讯作者：
Cai J
中科院分区：
文献类型：
--
作者：
Li J;Zhao F;Wang Y;Chen J;Tao J;Tian G;Wu S;Liu W;Cui Q;Geng B;Zhang W;Weldon R;Auguste K;Yang L;Liu X;Chen L;Yang X;Zhu B;Cai J
背景最近，肠道微生物组在代谢疾病，特别是心血管疾病中的潜在作用已被揭示。高血压是全球最常见的心血管疾病之一，但肠道菌群失调是否参与高血压的发生仍很大程度上未知。为了研究这个问题，我们对 41 名健康对照者、56 名高血压前期受试者、99 名原发性高血压受试者进行了全面的宏基因组和代谢组学分析，并将患者粪便微生物群移植到无菌小鼠中。结果与健康对照者相比，我们发现微生物丰富度和多样性显着下降，普雷沃氏菌为主的肠道肠型，独特的宏基因组组成，其中与健康状况相关的细菌减少以及细菌过度生长，例如如普雷沃氏菌和克雷伯氏菌，以及高血压前期和高血压人群中与疾病相关的微生物功能。出乎意料的是，高血压前期组的微生物组特征与高血压组非常相似。高血压前期或高血压宿主的代谢变化被认为与肠道微生物群失调密切相关。并构建了基于微生物群和代谢物的疾病分类器，以准确地区分高血压前期和高血压个体与对照组。此外，通过将高血压人类供体的粪便移植到无菌小鼠体内，观察到血压升高可通过微生物群转移，并证明了肠道微生物群对宿主血压的直接影响。结论总的来说，我们的结果描述了异常肠道微生物群在高血压发病机制中的一种新的因果作用。并强调了高血压前期早期干预的意义。
BackgroundRecently, the potential role of gut microbiome in metabolic diseases has been revealed, especially in cardiovascular diseases. Hypertension is one of the most prevalent cardiovascular diseases worldwide, yet whether gut microbiota dysbiosis participates in the development of hypertension remains largely unknown. To investigate this issue, we carried out comprehensive metagenomic and metabolomic analyses in a cohort of 41 healthy controls, 56 subjects with pre-hypertension, 99 individuals with primary hypertension, and performed fecal microbiota transplantation from patients to germ-free mice.ResultsCompared to the healthy controls, we found dramatically decreased microbial richness and diversity,Prevotella-dominated gut enterotype, distinct metagenomic composition with reduced bacteria associated with healthy status and overgrowth of bacteria such asPrevotellaandKlebsiella, and disease-linked microbial function in both pre-hypertensive and hypertensive populations. Unexpectedly, the microbiome characteristic in pre-hypertension group was quite similar to that in hypertension. The metabolism changes of host with pre-hypertension or hypertension were identified to be closely linked to gut microbiome dysbiosis. And a disease classifier based on microbiota and metabolites was constructed to discriminate pre-hypertensive and hypertensive individuals from controls accurately. Furthermore, by fecal transplantation from hypertensive human donors to germ-free mice, elevated blood pressure was observed to be transferrable through microbiota, and the direct influence of gut microbiota on blood pressure of the host was demonstrated.ConclusionsOverall, our results describe a novel causal role of aberrant gut microbiota in contributing to the pathogenesis of hypertension. And the significance of early intervention for pre-hypertension was emphasized.