Clinical utility of 3% diquafosol ophthalmic solution in the treatment of dry eyes.
Clinical utility of 3% diquafosol ophthalmic solution in the treatment of dry eyes.
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DOI：
10.2147/opth.s69486
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Koh S
中科院分区：
文献类型：
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作者：
Koh S
Diquafosol是一种治疗干眼症的药物，具有新的作用机制。它刺激泪液和眼表粘蛋白的分泌，从而使我们能够有选择地治疗泪膜层，在日本干眼的有效治疗方法-泪膜导向疗法(TFOT)的概念建立中发挥了重要作用。3%地喹磷滴眼液在临床实践中被广泛用于治疗干眼，目前在日本和韩国都有售。本文综述了3%地喹磷滴眼液的临床应用，重点介绍了各种类型干眼的临床研究结果，包括缺水干眼、泪膜破裂时间短的干眼和准分子激光原位角膜磨镶术后干眼。并介绍了地喹硫醇在玻璃酸钠单一治疗干眼症中的相加作用，以及3%地喹硫醇滴眼液对干眼症的治疗效果。此外，它还总结了地喹硫醇对健康人眼睛的影响。最后，描述了提高泪膜稳定性在干眼治疗中的重要性，以及干眼治疗的一般进展。
Diquafosol is a drug used for dry eye treatment with a novel mechanism of action. It stimulates the secretion of tear fluid and mucin on the ocular surface, thus enabling us to selectively treat the tear film layer, playing an important role in the establishment of the concept of “Tear Film Oriented Therapy (TFOT)”, an effective therapeutic approach to dry eye in Japan. The 3% diquafosol ophthalmic solution has been widely used for the treatment of dry eye in clinical practice, and it is currently available in Japan and South Korea. This review provides an overview of the clinical utility of 3% diquafosol ophthalmic solution, focusing on the results of clinical studies on various types of dry eye, including aqueous-deficient dry eye, short tear film breakup time-type dry eye, and post dry eye after laser in situ keratomileusis. It also introduces the additive effect of diquafosol on sodium hyaluronate monotherapy for dry eye, and the effect of 3% diquafosol ophthalmic solution for dry eye-related conditions. Additionally, it summarizes the ocular effects of diquafosol in healthy human eyes. Lastly, the importance of improving tear film stability in dry eye treatment, as well as general advances in dry eye treatments, are described.