OLETF (OTSUKA LONG-EVANS TOKUSHIMA FATTY) RAT - A NEW NIDDM RAT STRAIN
OLETF (OTSUKA LONG-EVANS TOKUSHIMA FATTY) RAT - A NEW NIDDM RAT STRAIN
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DOI：
10.1016/0168-8227(94)90269-0
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发表时间：
1994-10-01
影响因子：
5.1
通讯作者：
NATORI, T
中科院分区：
文献类型：
--
作者：
KAWANO, K;HIRASHIMA, T;NATORI, T
OLETF大鼠的特点是：（1）迟发性高血糖（2）慢性病程;（3）轻度肥胖;（4）糖尿病（DM）临床发病多见于男性;（5）遗传特征：（a）多个隐性基因参与DM的诱导;（B）大鼠MHC、RT 1无致糖尿病作用;（c）对照品系LETO似乎与OLETF大鼠共享一些致糖尿病基因;（d）雌性OLETF大鼠也携带致糖尿病基因;和（e）其中一个致糖尿病基因，命名为odb-1，与OLETF大鼠的X染色体传递连锁，然而睾酮是参与发展糖尿病的重要因素;（6）胰岛的变化可分为三个阶段：（1）早期（小于9周龄）轻度淋巴细胞浸润;（2）增生期（10-40周龄）;胰岛内或周围的增生性变化和纤维化;（3）终末期（大于40周龄）显示胰岛萎缩;（7）糖尿病肾病;（a）弥漫性肾小球硬化;（B）结节性病变（基底膜增厚、系膜增生、纤维蛋白帽）。OLETF大鼠疾病的这些临床和病理特征与人类NIDDM相似。
The characteristic features of OLETF rats are: (1) late onset of hyperglycemia (after 18 weeks of age); (2) a chronic course of disease; (3) mild obesity; (4) clinical onset of diabetes mellitus (DM) mostly in males; (5) hereditary trait: (a) multiple recessive genes are involved in the induction of DM; (b) rat MHC, RT1 has no diabetogenic effect; (c) control strain, LETO appears to share some of diabetogenic genes with OLETF rats; (d) female OLETF rats also carry diabetogenic genes; and (e) one of the diabetogenic genes, designated as odb-1, is transmitted linked with the X-chromosome of OLETF rats, however testosterone is an important factor involved in developing diabetes; (6) the changes of pancreatic islets can be classified into three stages: (1) an early stage (at less than 9 weeks of age) mild lymphocyte infiltration; (2) a hyperplastic stage (10-40 weeks of age); hyperplastic change and fibrosis in or around islets; (3) a final stage (at more than 40 weeks of age) showing atrophy of islets; (7) diabetic nephropathy; (a) diffuse glomerulosclerosis; (b) nodular lesion (thickening of basement membranes, mesangial proliferation, fibrin cap). These clinical and pathologic features of disease in OLETF rats resemble those of human NIDDM.