New insights into the central PACAPergic system from the phenotypes in PACAP- and PACAP receptor-knockout mice
New insights into the central PACAPergic system from the phenotypes in PACAP- and PACAP receptor-knockout mice
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DOI：
10.1196/annals.1317.038
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发表时间：
2006-01-01
期刊：
影响因子：
--
通讯作者：
Baba, Akemichi
中科院分区：
文献类型：
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作者：
Hashimoto, Hitoshi;Shintani, Norihito;Baba, Akemichi
垂体腺苷环化酶激活多肽(PACAP)是一种结构高度保守的神经肽，具有多种功能，包括神经递质、神经调节剂和神经营养因子。最近的一系列实验，包括对PACAP及其受体的遗传操作，使人们更好地理解了PACAP被认为在其中发挥作用的正常和病理过程，并揭示了内源性PACAP的未知功能。本文的目的是简要综述PACAP在PACAP及其受体缺陷小鼠中枢神经系统中作用的最新进展，特别是在行为和神经特征方面，包括精神运动行为、摄食、应激反应、记忆表现、酒精敏感性、慢性疼痛和昼夜节律。这篇文章还讨论了它们与人类疾病的潜在关系。
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a structurally highly conserved neuropeptide and displays pleiotropic activity, including functioning as a neurotransmitter, neuromodulator, and neurotrophic factor. A series of recent experiments, including genetic manipulation of PACAP and its receptors, has led to better understanding of both normal and pathological processes in which PACAP has been proposed to play a role, and sheds light on previously uncharacterized functions of endogenous PACAP, The aim of this article is to briefly review the recent advances in understanding the role of PACAP in the central nervous system from PACAP- and PACAP receptor-deficient mice, particularly with respect to behavioral and neurological features, including psychomotor behavior, feeding, stress responses, memory performance, ethanol sensitivity, chronic pain, and circadian rhythms. This article also discusses their potential involvement in human diseases.