The effect of prenatal morphine exposure on memory consolidation in the chick
The effect of prenatal morphine exposure on memory consolidation in the chick
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DOI：
10.1016/j.neulet.2005.01.061
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发表时间：
2005-06-03
影响因子：
2.5
通讯作者：
Ma, YY
中科院分区：
文献类型：
--
作者：
Che, Y;Sun, HY;Ma, YY
中枢神经系统在生命早期表现出显著的可塑性，可以通过产前吗啡暴露显着改变。先前的研究表明，产前吗啡暴露可能会改变产后雏鸡的学习和记忆能力。1日龄雏鸡单试验被动回避学习模式是研究记忆形成机制的一个很好的模型，包括短时记忆、短时记忆和长期记忆。以下是我们对产前吗啡暴露对小鸡学习和记忆缺陷的影响的研究。本实验采用单试验被动回避学习模式，在卵腔内注射吗啡（20 mg/kg），考察产前吗啡暴露对记忆巩固的影响。结果表明，从E12到E16每天注射吗啡的雏鸡在训练后120分钟的长期记忆明显受损（p < 0.001），但在训练后30分钟的中期记忆没有明显受损。2005爱思唯尔爱尔兰有限公司版权所有。
The central nervous system exhibits remarkable plasticity in early life and can be altered significantly by prenatal morphine exposure. Previous studies show that prenatal morphine exposure may alter the capacity for learning and memory in post-partum chicks. The one-trial passive avoidance learning paradigm with 1-day-old chicks is an excellent model to study several mechanisms of memory formation, including STM, ITM, and LTM. The following represents our investigation of the effect of prenatal morphine exposure on learning and memory deficits in the chick. In these experiments, morphine was injected into the airspace of eggs (20 mg/kg) and the one-trial passive avoidance learning paradigm was used to test the effect of prenatal morphine exposure on memory consolidation. The data suggest that chicks injected with morphine daily from E12 to E16 had significantly impaired long-term memory at 120 min after training (p < 0.001) but not intermediate-term memory at 30 min after training. (c) 2005 Elsevier Ireland Ltd. All rights reserved.