Dementia with Lewy bodies research consortia: A global perspective from the ISTAART Lewy Body Dementias Professional Interest Area working group.
Dementia with Lewy bodies research consortia: A global perspective from the ISTAART Lewy Body Dementias Professional Interest Area working group.
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DOI：
10.1002/dad2.12235
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
ISTAART Lewy body dementias Consortia Working Group
中科院分区：
文献类型：
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作者：
D'Antonio F;Kane JPM;Ibañez A;Lewis SJG;Camicioli R;Wang H;Yu Y;Zhang J;Ji Y;Borda MG;Kandadai RM;Babiloni C;Bonanni L;Ikeda M;Boeve BF;Leverenz JB;Aarsland D;ISTAART Lewy body dementias Consortia Working Group
在过去的三十年里，路易体痴呆(DLB)的研究在国际合作中有了显著的增长。然而，研究人员在识别能够为纵向研究和临床试验提供动力的大样本和多样化样本方面面临着挑战。后勤基地研究界已开始将重点放在支持联合体的发展和协调上，同时还继续建立网络，以便在其中共享数据和研究结果。这篇文章描述了各大洲DLB研究合作的现状。我们讨论了几个已经建立的DLB队列，其中许多已经采用了一个共同的框架，并确定了新出现的协作倡议，这些倡议具有扩大DLB网络和使研究队列多样化的潜力。我们的调查结果确定了全球后勤基地网络应寻求扩展的地理领域，我们提出了一些战略，如建立数据共享平台和统一议定书，这可能会进一步加强国际合作。
Dementia with Lewy bodies (DLB) research has seen a significant growth in international collaboration over the last three decades. However, researchers face a challenge in identifying large and diverse samples capable of powering longitudinal studies and clinical trials. The DLB research community has begun to focus efforts on supporting the development and harmonization of consortia, while also continuing to forge networks within which data and findings can be shared. This article describes the current state of DLB research collaborations on each continent. We discuss several established DLB cohorts, many of whom have adopted a common framework, and identify emerging collaborative initiatives that hold the potential to expand DLB networks and diversify research cohorts. Our findings identify geographical areas into which the global DLB networks should seek to expand, and we propose strategies, such as the creation of data‐sharing platforms and the harmonization of protocols, which may further potentiate international collaboration.