Elevated soluble ST2 protein levels in sera of patients with asthma with an acute exacerbation
Elevated soluble ST2 protein levels in sera of patients with asthma with an acute exacerbation
复制标题
DOI：
10.1164/ajrccm.164.2.2008120
复制
发表时间：
2001-07-15
影响因子：
24.7
通讯作者：
Sugiyama, Y
中科院分区：
文献类型：
--
作者：
Oshikawa, K;Kuroiwa, K;Sugiyama, Y
先前的研究已经报道ST 2优先表达于Th 2细胞，并且在控制哮喘小鼠模型的气道炎症中起关键作用。然而，ST 2在支气管哮喘患者中的临床作用仍不清楚。在我们的研究中，我们检测了56例非发作期特应性哮喘患者和200例非特应性正常志愿者作为健康对照，并分析了他们的血清ST 2水平与哮喘严重程度、肺功能和实验室数据的关系。在56例特应性哮喘患者中，30例出现哮喘急性发作，并分析其血清ST 2水平。血清ST 2水平较低，但与健康对照组比较差异有统计学意义（P < 0.05）。我们还发现血清ST 2水平的差异性升高与哮喘急性发作的严重程度密切相关。此外，哮喘急性发作期间的血清ST 2水平与预测的呼气峰流速百分比（r =-0.634，p = 0.004）和Pa-CO2（r = 0.516，p = 0.003）在统计学上相关。这些结果表明，可溶性人ST 2蛋白在血清中可能与Th 2介导的过敏性炎症诱导急性发作的特应性哮喘患者。
Previous studies have reported that ST2 is preferentially expressed on Th2 cells and plays a critical part in controlling airway inflammation in murine models of asthma. However, the clinical role of ST2 in patients with bronchial asthma remains unclear. In our study, we examined 56 patients with atopic asthma in a nonattack phase and 200 nonatopic normal volunteers for healthy control, and analyzed the relationship of their serum ST2 levels to asthma severity, pulmonary function, and laboratory data. Of the 56 patients with atopic asthma, 30 exhibited asthmatic exacerbation, and their serum ST2 levels were also analyzed. The serum ST2 levels were low, but a statistical difference was found between patients with nonattack asthma and the healthy control group (p < 0.05). We also found a differential rise of serum ST2 level that correlates well with the severity of asthma exacerbation. Furthermore, the serum ST2 levels during asthma exacerbation statistically correlated with the percentage of predicted peak expiratory flow (r = -0.634, p = 0.004) and Pa-CO2 (r = 0.516, p = 0.003). These results suggest that soluble human ST2 protein in sera may be related to Th2-mediated allergic inflammation inducing acute exacerbation in patients with atopic asthma.