Medium-Term Effects of Insulin Degludec on Patients with Type 1 Diabetes Mellitus
Medium-Term Effects of Insulin Degludec on Patients with Type 1 Diabetes Mellitus
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DOI：
10.1007/s40268-014-0048-6
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发表时间：
2014-06-01
期刊：
影响因子：
3
通讯作者：
Namba, Mitsuyoshi
中科院分区：
文献类型：
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作者：
Nakae, Rie;Kusunoki, Yoshiki;Namba, Mitsuyoshi
目的分析1型糖尿病（T1 DM）患者在基础-餐时胰岛素治疗中由甘精胰岛素或地特胰岛素转换为德谷胰岛素后每日血糖波动和胰岛素剂量的变化。所有接受甘精胰岛素或地特胰岛素每日两次治疗的患者均转换为德谷胰岛素，剂量为既往胰岛素剂量的80- 90%。研究期间，主治医生调整基础胰岛素剂量。患者在转换为德谷胰岛素前、转换为德谷胰岛素后3天和转换为德谷胰岛素后24周接受了动态血糖监测。在转换前、转换后3天和转换后24周分析每日胰岛素剂量。在转换前和转换后24周检测糖化血红蛋白水平。结果转换前后血糖谱无明显变化。另一方面，每日总胰岛素剂量和每日总基础胰岛素剂量显着降低24 weeks后switching.Discussion在接受甘精胰岛素或地特胰岛素治疗的T1 DM患者中，有可能达到类似的血糖控制在中期与每日一次，较低剂量的德谷胰岛素。
Objective The aim of this study was to analyze the changes in daily blood glucose fluctuation and insulin dose in patients with type 1 diabetes mellitus (T1DM) undergoing basal-bolus therapy following a switching of basal insulin used from insulin glargine or detemir to insulin degludec.Methods Seven patients with T1DM were enrolled. All patients treated with insulin glargine or detemir twice daily were switched to insulin degludec with 80-90 % of the prior insulin dose. During the study period, the basal insulin doses were adjusted by the attending physician. The patients underwent continuous glucose monitoring before, 3 days after, and 24 weeks after switching to insulin degludec. The daily insulin dose was analyzed before, 3 days after, and 24 weeks after switching. Glycated hemoglobin levels were measured before and 24 weeks after switching.Results The blood glucose profile did not change significantly before and after switching. On the other hand, the total daily insulin dose and total daily basal insulin dose decreased significantly 24 weeks after switching.Discussion In patients with T1DM undergoing insulin glargine or detemir treatment, it is possible to achieve similar glycemic control in the medium term with a once daily, lower dose of insulin degludec.