Emerging extranuclear roles of protein SUMOylation in neuronal function and dysfunction.
Emerging extranuclear roles of protein SUMOylation in neuronal function and dysfunction.
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DOI：
10.1038/nrn2276
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发表时间：
2007-12
影响因子：
34.7
通讯作者：
Henley, Jeremy M.
中科院分区：
文献类型：
--
作者：
Martin, Stephane;Wilkinson, Kevin A.;Nishimune, Atsushi;Henley, Jeremy M.
翻译后蛋白修饰是信号级联反应的组成部分，它使细胞能够有效、快速和可逆地响应细胞外刺激。这些变化在中枢神经系统中起着至关重要的作用，中枢神经系统中神经元之间的交流尤为复杂。SUMO修饰是一种翻译后修饰，其中小泛素样修饰物（SUMO）蛋白家族的一个成员与靶蛋白中的赖氨酸残基结合。众所周知，SUMOylation控制着核功能的许多方面，但现在清楚的是，它也是许多核外神经元过程的关键决定因素，并且它也涉及广泛的神经病理状况。
Post-translational protein modifications are integral components of signalling cascades that enable cells to efficiently, rapidly and reversibly respond to extracellular stimuli. These modifications have crucial roles in the CNS, where the communication between neurons is particularly complex. SUMOylation is a post-translational modification in which a member of the small ubiquitin-like modifier (SUMO) family of proteins is conjugated to lysine residues in target proteins. It is well established that SUMOylation controls many aspects of nuclear function, but it is now clear that it is also a key determinant in many extranuclear neuronal processes, and it has also been implicated in a wide range of neuropathological conditions.
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影响因子：
8
作者：
Besnault-Mascard, L;Leprince, C;Vazquez, A
通讯作者：
Vazquez, A
影响因子：
21.3
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4.1
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16
作者：
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