PERCEIVED SOCIAL SUPPORT AND TUMOR ESTROGEN PROGESTERONE-RECEPTOR STATUS AS PREDICTORS OF NATURAL-KILLER-CELL ACTIVITY IN BREAST-CANCER PATIENTS
PERCEIVED SOCIAL SUPPORT AND TUMOR ESTROGEN PROGESTERONE-RECEPTOR STATUS AS PREDICTORS OF NATURAL-KILLER-CELL ACTIVITY IN BREAST-CANCER PATIENTS
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DOI：
10.1097/00006842-199001000-00006
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发表时间：
1990-01-01
影响因子：
3.3
通讯作者：
KIRKWOOD, J
中科院分区：
文献类型：
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作者：
LEVY, SM;HERBERMAN, RB;KIRKWOOD, J
本报告涉及61例年龄在25岁至70岁之间的I期和II期乳腺癌患者的自然杀伤（NK）细胞活性预测。所有基线访谈和测试数据都是在患者出院前或出院后两周内首次门诊访视时获得的。这个项目的一个主要兴趣是感知社会支持的预测价值，作为一个潜在的“压力”缓冲，与NK活动。在这里报道的主要模型中，我们发现NK活性的显著差异可以用五个变量来解释。较高的NK活性可以通过感知来自配偶或亲密他人的高质量情感支持、感知来自患者医生的社会支持、雌激素受体阴性肿瘤状态、作为手术治疗的切除活检以及积极寻求社会支持作为主要应对策略来预测（R2= 0.33，F（5，55）= 5.5，p小于0.0004）。讨论了宿主与肿瘤内分泌状态的相互作用以及社会支持在调节此类活动中可能发挥的作用。
This report is concerned with the prediction of natural killer (NK) cell activity in 61 Stage I and II breast cancer patients, between the ages of 25 and 70, who were accrued to this project. All baseline interview and testing data were obtained either just before patients were discharged from the hospital, or at their first outpatient visit, within two weeks of discharge. A major interest of this project is the predictive value of perceived social support, as a potential “stress” buffer, related to NK activity. In the main model reported here, we found that a significant amount of NK activity variance could be explained by five variables. Higher NK activity could be predicted by the perception of high quality emotional support from a spouse or intimate other, perceived social support from the patient's physician, estrogen receptor-negative tumor status, having an excisional biopsy as surgical treatment, and actively seeking social support as a major coping strategy (R2= 0.33, F (5, 55)= 5.5, p less than 0.0004). Findings are discussed in terms of host interaction with tumor endocrine status, and the role that social support might play in modulating such activity.