Additive hazards regression with random effects for clustered failure times
Additive hazards regression with random effects for clustered failure times
复制标题
具有集群故障时间随机效应的附加危险回归
DOI：
10.1007/s10114-015-3628-7
复制
发表时间：
2015-03-01
影响因子：
0.7
通讯作者：
Wu, Yuan Shan
中科院分区：
文献类型：
--
作者：
Pan, Deng;Liu, Yan Yan;Wu, Yuan Shan
Additive hazards model with random effects is proposed for modelling the correlated failure time data when focus is on comparing the failure times within clusters and on estimating the correlation between failure times from the same cluster, as well as the marginal regression parameters. Our model features that, when marginalized over the random effect variable, it still enjoys the structure of the additive hazards model. We develop the estimating equations for inferring the regression parameters. The proposed estimators are shown to be consistent and asymptotically normal under appropriate regularity conditions. Furthermore, the estimator of the baseline hazards function is proposed and its asymptotic properties are also established. We propose a class of diagnostic methods to assess the overall fitting adequacy of the additive hazards model with random effects. We conduct simulation studies to evaluate the finite sample behaviors of the proposed estimators in various scenarios. Analysis of the Diabetic Retinopathy Study is provided as an illustration for the proposed method.
