The cardiopulmonary effects of sodium fluoroacetate (1080) in Sprague-Dawley rats
The cardiopulmonary effects of sodium fluoroacetate (1080) in Sprague-Dawley rats
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DOI：
10.1080/23312025.2019.1568669
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发表时间：
2019-01-17
期刊：
影响因子：
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通讯作者：
Wong, Benjamin
中科院分区：
文献类型：
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作者：
McCranor, Bryan J.;Young, Talearia D.;Wong, Benjamin
氟乙酸钠（1080）是一种高毒性代谢毒物，由于其缺乏明确的颜色，气味和味道以及其高水溶性，因此有可能通过食品掺假有意或无意地摄入。虽然1080的作用机制自20世纪50年代以来就已为人所知，但还没有已知的解毒剂。为了更好地了解1080的心肺影响，我们使用全身体积描记法和遥测Sprague-Dawley大鼠，其允许使用非侵入性辅助饮水方法在暴露后实时测量呼吸和心脏参数。总体而言，动物在暴露后24小时内显示呼吸参数明显下降，肺组织出现出血。在暴露后24 h，男性潮气量减少30%，女性减少60%，呼吸频率也显著降低。在遥测雌性大鼠中，我们观察到严重的心脏异常，突出表现为心率降低50%，收缩压降低75%，QRS间期延长3.5倍。我们还观察到核心体温降低了近15摄氏度。我们的研究能够描述氟乙酸钠中毒对心肺功能的严重和显著影响，其结果表明，组织特异性和全身性缺陷都有助于1080中毒的毒理学进展，在制定任何潜在的对策1080中毒时需要考虑。
Sodium fluoroacetate (1080) is a highly toxic metabolic poison that has the potential because of its lack of defined color, odor, and taste and its high water solubility to be intentionally or unintentionally ingested through food adulteration. Although the mechanism of action for 1080 has been known since the 1950s, no known antidote exists. In an effort to better understand the cardiopulmonary impacts of 1080, we utilized whole-body plethysmography and telemeterized Sprague-Dawley rats which allowed for the real-time measurement of respiratory and cardiac parameters following exposure using a non-invasive assisted-drinking method. Overall, the animals showed marked depression of respiratory parameters over the course of 24 h post-exposure and the development of hemorrhage in the lung tissue. Tidal volume was reduced by 30% in males and 60% in females at 24 h post-exposure, and respiratory frequency was significantly depressed as well. In telemeterized female rats, we observed severe cardiac abnormalities, highlighted by a 50% reduction in heart rate, 75% reduction in systolic blood pressure, and a 3.5-fold lengthening of the QRS interval over the course of 24 h. We also observed a reduction in core body temperature of nearly 15 degrees C. Our study was able to describe the severe and pronounced effects of sodium fluoroacetate poisoning on cardiopulmonary function, the results of which indicate that both tissue specific and systemic deficits contribute to the toxicological progression of 1080 intoxication and will need to be accounted for when developing any potential countermeasure for 1080 poisoning.