Do antipsychotic drugs increase seizure frequency in epilepsy patients?
Do antipsychotic drugs increase seizure frequency in epilepsy patients?
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DOI：
10.1016/j.euroneuro.2014.09.012
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发表时间：
2014-11-01
影响因子：
5.6
通讯作者：
Onuma, Teiichi
中科院分区：
文献类型：
--
作者：
Okazaki, Mitsutoshi;Adachi, Naoto;Onuma, Teiichi
为了探讨在已接受抗癫痫药物(AED)治疗的癫痫患者中加用抗精神病药物是否会增加癫痫发作的频率，我们比较了150例因精神疾病而接受抗精神病药物治疗的癫痫患者和309例未接受抗精神病药物治疗的癫痫患者一年的癫痫控制结果，这些患者的发病年龄与癫痫的基线评估和类型相匹配。分别于治疗前、治疗后1、3、6、12个月记录癫痫发作次数。将四个随访点的癫痫发作结果与基线进行比较。根据癫痫的类型(特发性癫痫、全身性癫痫和部分性癫痫)，比较两组的癫痫发作结果。在apd组，还根据apd的类型(第一代和第二代apd以及第一代和第二代apd的组合)和精神疾病的类型(精神病和非精神病)来分析癫痫的结局。在所有4个随访点，观察组癫痫发作结果均明显好于对照组。根据癫痫类型，癫痫预后的改善仅见于部分性癫痫。在apd组中，不同的apd类型和不同的精神状态在癫痫发作结果上没有显著差异。对于已经接受AED治疗的癫痫患者，对于精神疾病的治疗而言，在癫痫控制结果中，apd治疗似乎是安全的。(C)2014年爱思唯尔和ECNP。版权所有。
To investigate whether addition of antipsychotic drugs (APD) would increase seizure frequency in epilepsy patients who were already treated with anti-epileptic drugs (AED), we compared a one-year seizure control outcome in 150 epilepsy patients with APD treatment for psychiatric conditions and 309 epilepsy patients without APD treatment matched for ages at epilepsy onset and the baseline evaluation and types of epilepsy. The seizure frequency was recorded at the baseline (immediately before the start of APD) and after the 1st, 3rd, 6th and 12th months. The seizure outcome at each of the four follow-up points was compared with the baseline. The seizure outcome was compared between the two groups as a whole and according to the types of epilepsy (idiopathic generalized and partial epilepsies). In the APD group, the seizure outcome was also analyzed according to the types of APD (first and second generation APD and combination of first and second generation APD) and the types of psychiatric conditions (psychosis and non-psychosis). The seizure outcome was significantly better in the APD group than control group at all the four follow-up points. According to the epilepsy types, the improvement in the seizure outcome was only observed in the patients with partial epilepsy. Of the APD group, there was no significant difference in the seizure outcome according to the types of APD or the psychiatric conditions. In epilepsy patients who are already treated with AED, APD treatment seems safe in seizure control outcome for treatment of psychiatric conditions. (C) 2014 Elsevier B.V. and ECNP. All rights reserved.