Metallacycle-Mediated Cross-Coupling with Substituted and Electronically Unactivated Alkenes.
Metallacycle-Mediated Cross-Coupling with Substituted and Electronically Unactivated Alkenes.
复制标题
DOI：
10.1039/c0sc00394h
复制
发表时间：
2011
期刊：
影响因子：
8.4
通讯作者：
Micalizio GC
中科院分区：
文献类型：
--
作者：
Reichard HA;Micalizio GC
本文综述了金属环介导的取代烯烃偶联化学的历史和最新进展。虽然预成形金属- π配合物与乙烯的反应在近30年前就有报道，但将这种双分子C-C键形成模式推广到复杂底物的区域和立体选择性结合只是最近才开始出现。本观点讨论了这一领域的早期观察，与控制这一过程相关的挑战，克服这些挑战的一般策略的演变，以及目前通过金属环介导的与取代烯烃的交叉偶联可获得的高度区域和立体选择性的会聚偶联反应的总结。
This perspective surveys the history of- and recent advances in- metallacycle-mediated coupling chemistry of substituted alkenes. While the reaction of preformed metal–π complexes with ethylene was reported nearly 30 years ago, the generalization of this mode of bimolecular C–C bond formation to the regio- and stereoselective union of complex substrates has only recently begun to emerge. This perspective discusses early observations in this area, the challenges associated with controlling such processes, the evolution of a general strategy to overcome these challenges, and a summary of highly regio- and stereoselective convergent coupling reactions that are currently available by metallacycle-mediated cross-coupling with substituted alkenes.