OLIGODENDROGLIAL MICROTUBULAR TANGLES IN OLIVOPONTOCEREBELLAR ATROPHY
OLIGODENDROGLIAL MICROTUBULAR TANGLES IN OLIVOPONTOCEREBELLAR ATROPHY
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DOI：
10.1097/00005072-199009000-00007
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发表时间：
1990-09-01
影响因子：
3.2
通讯作者：
YAMAGUCHI, H
中科院分区：
文献类型：
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作者：
NAKAZATO, Y;YAMAZAKI, H;YAMAGUCHI, H
少突胶质细胞微管缠结（OMT），一个独特的少突胶质细胞的变化，观察在7例橄榄桥脑小脑萎缩（OPCA）。这种变化是一个明确的玻璃状细胞质结构，显示强烈的嗜银性。OMT分布于脑干、小脑和基底节，在这些部位持续观察到严重的神经退行性改变。在45例对照病例中，无论是否存在神经系统疾病，均未发现OMT。OMT用抗微管蛋白抗体免疫染色，但没有其他抗体与它们反应。每个OMT由随机取向的原纤维组成的网状结构，其中布满了颗粒状和绒毛状材料。纳米粒子的直径在20 ~ 30 nm之间。提示OMT主要由改变的微管组成，并与OPCA的神经发生过程有关。
Oligodendroglial microtubular tangles (OMT), a distinctive oligodendroglial change, was observed in seven of eight cases of olivopontocerebellar atrophy (OPCA). This change was a well-defined glassy cytoplasmic structure showing intense aryrophilia. OMT were distributed in the brain stem, cerebellum, and basal ganglia where severe neurodegenerative changes were consistently observed. In 45 control cases, no OMT were found regardless of the presence or absence of neurological disorders. The OMT were immunostained by anti-tubulin antibodies, but no other antibodies reacted with them. Each OMT consisted of a meshwork of randomly oriented fibrils studded with granular and fuzzy material. The fibrillary elements were between 20 and 30 nm in diameter. It is suggested that OMT are primarily composed of altered microtubules, and are related to the neurogenerative process of OPCA.