No effect of cancer-associated SNP rs6983267 in the 8q24 region on co-expression of MYC and TCF7L2 in normal colon tissue.
No effect of cancer-associated SNP rs6983267 in the 8q24 region on co-expression of MYC and TCF7L2 in normal colon tissue.
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DOI：
10.1186/1476-4598-8-96
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发表时间：
2009-11-06
期刊：
影响因子：
37.3
通讯作者：
Hall JL
中科院分区：
文献类型：
--
作者：
Prokunina-Olsson L;Hall JL
位于8 q24区域内的单核苷酸多态性（SNP）rs6983267与结直肠癌和前列腺癌的风险密切相关。已经表明，这种关联的机制与TCF 7 L2蛋白（以前称为TCF-4）与rs6983267等位基因的差异相互作用有关，影响位于335 Kb端粒的众所周知的癌基因MYC的表达。在这里，我们在117个非癌结肠样本中检测了MYC mRNA表达与TCF 7 L2几种可变剪接形式之间的相关性。我们观察到MYC的表达与TCF 7 L2的独特剪接形式之间存在强相关性（r = 0.60，p < 10-6）。这些样本中MYC表达水平与某些TCF 7 L2剪接形式的表达相关，但与rs6983267基因型或rs6983267与TCF 7 L2表达的相互作用无关。这些发现表明，TCF 7 L2的某些剪接形式可能对结肠组织中MYC表达的调节具有重要的功能，但这种调节并不直接依赖于rs6983267。
A single nucleotide polymorphism (SNP) rs6983267, located within the 8q24 region, is strongly associated with risk of colorectal and prostate cancer. It has been suggested that the mechanism of this association is related to differential interaction of TCF7L2 protein (previously known as TCF-4) with alleles of rs6983267, influencing the expression of a well-known oncogene, MYC, located 335 Kb telomeric. Here, we tested the correlation between mRNA expression of MYC and several alternatively spliced forms of TCF7L2 in 117 non-cancer colon samples. We observed a strong correlation (r = 0.60, p < 10-6) between expression of MYC and a unique splicing form of TCF7L2. The level of MYC expression in these samples was associated with expression of some TCF7L2 splicing forms but not with genotypes of rs6983267, or interaction of rs6983267 with TCF7L2 expression. These findings suggest that some splicing forms of TCF7L2 may be functionally important for regulation of MYC expression in colon tissue but this regulation is not directly dependent on rs6983267.
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影响因子：
64.8
作者：
Sansom, Owen J.;Meniel, Valerie S.;Clarke, Alan R.
通讯作者：
Clarke, Alan R.
影响因子：
30.8
作者：
Pomerantz, Mark M.;Ahmadiyeh, Nasim;Jia, Li;Herman, Paula;Verzi, Michael P.;Doddapaneni, Harshavardhan;Beckwith, Christine A.;Chan, Jennifer A.;Hills, Adam;Davis, Matt;Yao, Keluo;Kehoe, Sarah M.;Lenz, Heinz-Josef;Haiman, Christopher A.;Yan, Chunli;Henderson, Brian E.;Frenkel, Baruch;Barretina, Jordi;Bass, Adam;Tabernero, Josep;Baselga, Jose;Regan, Meredith M.;Manak, J. Robert;Shivdasani, Ramesh;Coetzee, Gerhard A.;Freedman, Matthew L.
通讯作者：
Freedman, Matthew L.
影响因子：
11.2
作者：
Pomerantz MM;Beckwith CA;Regan MM;Wyman SK;Petrovics G;Chen Y;Hawksworth DJ;Schumacher FR;Mucci L;Penney KL;Stampfer MJ;Chan JA;Ardlie KG;Fritz BR;Parkin RK;Lin DW;Dyke M;Herman P;Lee S;Oh WK;Kantoff PW;Tewari M;McLeod DG;Srivastava S;Freedman ML
通讯作者：
Freedman ML
影响因子：
56.9
作者：
He, TC;Sparks, AB;Kinzler, KW
通讯作者：
Kinzler, KW
DOI：
10.1158/1055-9965.epi-08-0523
发表时间：
2008-11
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Park SL;Chang SC;Cai L;Cordon-Cardo C;Ding BG;Greenland S;Hussain SK;Jiang Q;Liu S;Lu ML;Mao JT;Morgenstern H;Mu LN;Ng LJ;Pantuck A;Rao J;Reuter VE;Tashkin DP;You NC;Yu CQ;Yu SZ;Zhao JK;Belldegrun A;Zhang ZF
通讯作者：
Zhang ZF