The effect of timing of intrathecal fibrinolytic therapy on cerebral vasospasm in a primate model of subarachnoid hemorrhage.
The effect of timing of intrathecal fibrinolytic therapy on cerebral vasospasm in a primate model of subarachnoid hemorrhage.
复制标题
鞘内纤溶治疗时机对灵长类蛛网膜下腔出血模型脑血管痉挛的影响。
DOI：
10.1097/00006123-199002000-00003
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发表时间：
1990
期刊：
影响因子：
4.8
通讯作者：
Baughman,R
中科院分区：
文献类型：
--
作者：
Findlay,JM;Weir,BK;Kanamaru,K;Grace,M;Baughman,R
：检查了蛛网膜下腔出血后 0 至 72 小时内鞘内注射组织纤溶酶原激活剂对灵长类动物脑血管痉挛发生的影响。 30 只猴子被随机分为五个相等的组之一：对照组仅接受蛛网膜下腔出血，0、24、48 和 72 小时治疗组在基线脑血管造影和右侧蛛网膜下腔出血后分别接受 0.75 毫克组织纤溶酶原激活剂。 7天后，再次进行血管造影并处死动物。 72小时组中的一只动物在蛛网膜下腔出血后第7天出现迟发性缺血缺损。在对照组和72小时组中，大多数人都出现了明显的血管痉挛。右脑动脉（P < 0.05），但在0、24和48小时组中没有出现明显的血管痉挛。尽管对照组动物中仍然存在大的蛛网膜下腔血栓，但在所有治疗组中大多数血栓都已溶解。在蛛网膜下腔出血后 72 小时内用鞘内组织纤溶酶原激活剂溶解蛛网膜下腔血肿，可有效预防灵长类动物的血管痉挛。 (Neurosurgery 26: 201-206, 1990)
: The effect of intrathecal tissue plasminogen activator administered at times from 0 to 72 hours after subarachnoid hemorrhage on the development of cerebral vasospasm in primates was examined. Thirty monkeys were randomly assigned into one of five equal groups: a control group that underwent subarachnoid hemorrhage alone, and 0-, 24-, 48-, and 72-hour treatment groups that received 0.75 mg of tissue plasminogen activator at those times after baseline cerebral angiography and subarachnoid hemorrhage on the right side. Seven days later angiography was repeated and the animals were killed. One animal in the 72-hour group developed a delayed ischemic deficit on Day 7 after subarachnoid hemorrhage. In the control and 72-hour groups significant vasospasm occurred in most of the major. right cerebral arteries (P< 0.05), but no significant vasospasm developed in the 0-, 24-, and 48-hour groups, Although a large subarachnoid clot remained in the control animals, most clot had been dissolved in all treatment groups. Lysing of subarachnoid hematoma with intrathecal tissue plasminogen activator within 72 hours of subarachnoid hemorrhage is effective in preventing vasospasm in primates.(Neurosurgery 26: 201-206, 1990)