Exposure to trihalomethanes and adverse pregnancy outcomes
Exposure to trihalomethanes and adverse pregnancy outcomes
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DOI：
10.1097/00001648-199809000-00003
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发表时间：
1998-09-01
期刊：
影响因子：
5.4
通讯作者：
Savitz, DA
中科院分区：
文献类型：
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作者：
Gallagher, MD;Nuckols, JR;Savitz, DA
怀孕期间暴露于饮用水中的消毒副产品已被假设为导致几种不良的生殖结果。我们进行了一项回顾性队列研究，以检查妊娠晚期三卤甲烷暴露与低出生体重的关系。低出生体重和早产我们匹配科罗拉多出生证明从1990年1月1日，到1993年12月31日，历史水样数据的时间和地点的基础上人口普查块组的产妇居住。在排除了所有没有三卤甲烷样本数据的人口普查区块组的新生儿，并限制在妊娠28-42周（>400克）的单胎白色新生儿之后，我们研究了28个人口普查区块组中的1,893例活产婴儿。我们发现在妊娠晚期暴露于三卤甲烷与低出生体重之间存在微弱的关联（最高暴露水平的比值比= 2.1; 95%置信区间= 1.0-4.8）;在最高暴露水平下，足月低出生体重的风险大幅增加（比值比= 5.9; 95%置信区间= 2.0-17.0）;暴露与早产之间无关联（最高暴露水平的比值比= 1.0; 95%置信区间= 0.3-2.8）。少量的不良后果降低了风险估计的精度，但这些数据表明，妊娠晚期暴露于三卤甲烷和胎儿生长迟缓之间存在潜在的重要关系。
Exposure during pregnancy to disinfection by-products in drinking water has been hypothesized to lead to several adverse reproductive outcomes. We performed a retrospective cohort study to examine the relation of trihalomethane exposure during the third trimester of pregnancy to low birthweight, term. low birthweight, and preterm delivery. We matched Colorado birth certificates from January 1, 1990, through December 31, 1993, to historical water sample data with respect to time and location of maternal residence based on census block groups. After excluding births from all census block groups with no trihalomethane sample data and restricting to singleton white births with 28-42 weeks of completed gestation (>400 gm), we studied 1,893 livebirths within 28 census block groups. We found a weak association of trihalomethane exposure during the third trimester with low birthweight (odds ratio = 2.1 for the highest exposure level; 95% confidence interval = 1.0-4.8); a large increase in risk for term low birthweight at the highest level of exposure (odds ratio = 5.9; 95% confidence interval = 2.0-17.0); and no association between exposure and preterm delivery (odds ratio = 1.0 for the highest exposure level; 95% confidence interval = 0.3-2.8). The small number of adverse outcomes reduced the precision of risk estimates, but these data indicate a potentially important relation between third trimester exposure to trihalomethanes and retarded fetal growth.