Selecting Rational Drug Combinations in Epilepsy
Selecting Rational Drug Combinations in Epilepsy
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DOI：
10.1007/s40263-017-0471-7
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发表时间：
2017-10-01
期刊：
影响因子：
6
通讯作者：
Abou-Khalil, Bassel
中科院分区：
文献类型：
--
作者：
Abou-Khalil, Bassel
单药治疗仍然是癫痫的标准初始治疗，但当第一种抗癫痫药物（AED）失败时，可以考虑联合治疗。联合治疗的选择应考虑药代动力学相互作用以及与作用机制相关的药效学相互作用。有证据表明，具有不同作用机制的AED组合比具有相同机制的组合更有可能成功。拉莫三嗪和丙戊酸盐联合治疗已被证明具有协同疗效。然而，支持其他协同AED组合的数据有限。
Monotherapy remains the standard initial therapy of epilepsy, but when the first antiepileptic drug (AED) fails, combination therapy may be considered. The choice of combination therapy should take into consideration pharmacokinetic interactions, as well as pharmacodynamic interactions related to mechanism of action. There is evidence that an AED combination with different mechanisms of action is more likely to be successful than a combination with the same mechanisms. The combination of lamotrigine and valproate has been demonstrated to be synergistic in its efficacy. However, there are limited data to support other synergistic AED combinations.