A physical interpretation of the phenomenological coefficients of membrane permeability.
A physical interpretation of the phenomenological coefficients of membrane permeability.
复制标题
DOI：
10.1085/jgp.45.1.143
复制
发表时间：
1961-09
期刊：
影响因子：
--
通讯作者：
KATCHALSKY A
中科院分区：
文献类型：
--
作者：
KEDEM O;KATCHALSKY A
一个“翻译”的现象渗透系数到摩擦和分配系数服从物理解释。得到了非电解质和电解质渗透物的溶质渗透系数ω和反射系数σ的表达式。的系数的分析给出了松散的膜以及致密的天然膜，其中运输可能会通过毛细管或溶液中的类脂部分的膜。讨论了水的扩散和过滤过程及其与膜毛细孔半径的关系。对于离子渗透通过带电膜方程的情况下，零电流的膜。电解质的σ与ω和Lp的相关性与非电解质相似。在这种情况下，ω和σ明显取决于离子浓度和膜的电荷密度。反射系数可能呈现负值，指示异常渗透。对Teorell和Meyer以及Sievers模型的反常渗透现象进行了分析，其结果与Loeb和Grim和Sollner的实验数据相符合。本文提出了一组计算多价离子通过荷电膜时的ω和σ的方程和参考曲线。
A "translation" of the phenomenological permeability coefficients into friction and distribution coefficients amenable to physical interpretation is presented. Expressions are obtained for the solute permeability coefficient ω and the reflection coefficient σ for both non-electrolytic and electrolytic permeants. An analysis of the coefficients is given for loose membranes as well as for dense natural membranes where transport may go through capillaries or by solution in the lipoid parts of the membrane. Water diffusion and filtration and the relation between these and capillary pore radius of the membrane are discussed. For the permeation of ions through the charged membranes equations are developed for the case of zero electrical current in the membrane. The correlation of σ with ω and Lp for electrolytes resembles that for non-electrolytes. In this case ω and σ depend markedly on ion concentration and on the charge density of the membrane. The reflection coefficient may assume negative values indicating anomalous osmosis. An analysis of the phenomena of anomalous osmosis was carried out for the model of Teorell and Meyer and Sievers and the results agree with the experimental data of Loeb and of Grim and Sollner. A set of equations and reference curves are presented for the evaluation of ω and σ in the transport of polyvalent ions through charged membranes.