SIMULATION OF MECHANICAL TO NEURAL TRANSDUCTION IN THE AUDITORY RECEPTOR
SIMULATION OF MECHANICAL TO NEURAL TRANSDUCTION IN THE AUDITORY RECEPTOR
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DOI：
10.1121/1.393460
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发表时间：
1986-03-01
影响因子：
2.4
通讯作者：
MEDDIS, R
中科院分区：
文献类型：
--
作者：
MEDDIS, R
描述了毛细胞、听觉神经元 EPSP 的递质释放和放电模式的概率模型。该模型假设发射器的释放分数是刺激强度的函数。它还假设一些传递物质被带回细胞中，而另一些则从裂缝中不可挽回地丢失。这些假设不同于其他最近的模型，这些模型提出了多个释放位点、固定释放分数并且没有递质再摄取。该模型产生真实的哺乳动物速率强度函数、间隔和周期直方图、增量响应和适应效应。它成功地模拟了金鱼球囊传入神经元连续 EPSP 振幅的适应，并重新解释了这些研究对毛细胞突触机制的影响。
A probabilistic model is described for transmitter release from hair cells, auditory neuron EPSP''s, and discharge patterns. The model assumes that the release fraction of the transmitter is a function of stimulus intensity. It further assumes that some of this transmitter substance is taken back into the cell while some is irretrievably lost from the cleft. These assumptions differ from other recent models which propose multiple release sites, fixed release fractions, and no transmitter reuptake. The model produces realistic mammalian rate intensity functions, interval and period histograms, incremental responses, and adaptation effects. It mimics successfully the adaptation of successive EPSP amplitudes of the afferent neuron of the goldfish sacculus and offers a reinterpretation of the implications of these studies for hair cell synaptic mechanism.