Photoredox-Catalyzed Decarboxylative Cross-Coupling of α-Amino Acids with Nitrones
Photoredox-Catalyzed Decarboxylative Cross-Coupling of α-Amino Acids with Nitrones
复制标题
光氧化还原催化 α-氨基酸与硝酮的脱羧交叉偶联
DOI：
10.1021/acs.orglett.0c04101
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发表时间：
2021-01-12
期刊：
影响因子：
5.2
通讯作者：
Huang, Pei-Qiang
中科院分区：
文献类型：
--
作者：
Li, Heng-Hui;Li, Jia-Qi;Huang, Pei-Qiang
为了方便地合成结构多样性的β-氨基羟胺和邻二胺，建立了α-氨基酸与硝酮的可见光诱导光氧化还原脱羧偶联反应，该反应具有操作简单、条件温和、α-氨基酸易得、硝酮底物范围广等特点.该方法的应用为合成一些有价值的邻位二胺类化合物提供了有效的合成策略。
A decarboxylative cross-coupling reaction of alpha-amino acids with nitrones via visible-light-induced photoredox catalysis has been established for easy access to beta-amino hydroxylamines and vicinal diamines with structural diversity, which is featured with simple operation, mild conditions, readily available alpha-amino acids, and a broad scope of nitrone substrates. The application of this protocol can furnish efficient synthetic strategies for some valuable vicinal diamine-containing molecules.