Neurotoxic effects of organic solvents in exposed workers: an occupational, neuropsychological, and neurological investigation.
Neurotoxic effects of organic solvents in exposed workers: an occupational, neuropsychological, and neurological investigation.
复制标题
有机溶剂对接触工人的神经毒性作用：职业、神经心理学和神经学调查。
DOI：
10.1002/ajim.4700050305
复制
发表时间：
1984
影响因子：
3.5
通讯作者：
C. Uldal
中科院分区：
文献类型：
--
作者：
P. Gregersen;B. Angelsø;T. E. Nielsen;B. Nørgaard;C. Uldal
对98名工人（65名接触有机溶剂，33名未接触）进行了检查，以评估与溶剂接触有关的可能的神经毒性体征和症状。根据在特定工作过程中的暴露类型选择的研究组暴露于各种类型的溶剂。两组在年龄、脑外伤史和其他神经系统疾病史以及饮酒量方面具有可比性。接触过的工人有更多的智力障碍症状，在心理测试中表现较差，并且更常见的是脑性视疲劳的迹象。周围神经病变的症状和体征没有显著增加。研究组中溶剂暴露与神经毒性体征和症状轻度相关。这种剂量效应相关性以前仅在少数流行病学研究中得到证实。这就需要重新评估在长期职业性接触溶剂期间发生中毒性脑病的风险。
Ninety-eight workers, 65 exposed to organic solvents and 33 unexposed, were examined in order to assess possible neurotoxic signs and symptoms related to solvent exposure. The study group, who were selected according to the type of exposure in a given work process, had been exposed to various types of solvents. The groups were comparable in regard to age, the history of brain traumas and other neurological diseases, and alcohol consumption. The exposed workers had more symptoms of intellectual impairment, poorer performances in psychological tests, and more often signs of cerebral asthenopia. Symptoms and signs of peripheral neuropathy were not significantly increased. Solvent exposure and neurotoxic signs and symptoms were mildly correlated in the study group. Such dose-effect correlations have previously been proved only in a few epidemiological studies. This warrants reevaluation of the risk of developing toxic encephalopathy during prolonged occupational exposure to solvents.