Electrosprayed Synthesis of Red-Blood-Cell-Like Particles with Dual Modality for Magnetic Resonance and Fluorescence Imaging
Electrosprayed Synthesis of Red-Blood-Cell-Like Particles with Dual Modality for Magnetic Resonance and Fluorescence Imaging
复制标题
DOI：
10.1002/smll.201000399
复制
发表时间：
2010-11-05
期刊：
影响因子：
13.3
通讯作者：
Yogo, Toshinobu
中科院分区：
文献类型：
--
作者：
Hayashi, Koichiro;Ono, Kenji;Yogo, Toshinobu
红细胞（RBC）能够避免在脾脏中过滤，以延长其在体内的半衰期，因为它们的灵活性和独特的形状，或直径约10 μ m的凹盘。此外，它们可以通过变形为降落伞状形状而流过比红细胞直径小的毛细血管。在这项研究中，柔性RBC类聚合物颗粒的合成基于静电纺丝的电喷雾。此外，磁铁矿纳米颗粒和荧光染料通过在纤维素存在下铁有机化合物的原位水解包封在颗粒中。超顺磁性行为的颗粒被证实了低温磁性测量。该颗粒不仅在磁共振成像（MRI）中表现出暗对比度，而且还表现出有效的荧光。具有柔性的RBC样颗粒被证明具有用于MRI和荧光成像的双模态。
Red blood cells (RBCs) are able to avoid filtration in the spleen to prolong their half-time in the body because of their flexibility and unique shape, or a concave disk with diameter of some 10 mu m. In addition, they can flow through capillary blood vessels, which are smaller than the diameter of RBCs, by morphing into a parachute-like shape. In this study, flexible RBC-like polymer particles are synthesized by electrospraying based on electrospinning. Furthermore, magnetite nanoparticles and fluorescent dye are encapsulated in the particles via in situ hydrolysis of an iron-organic compound in the presence of celluloses. The superparamagnetic behavior of the particles is confirmed by low-temperature magnetic measurements. The particles exhibited not only a dark contrast in magnetic resonance imaging (MRI), but also effective fluorescence. The RBC-like particles with flexibility are demonstrated to have a dual-modality for MRI and fluorescence imaging.