Scene-selective cortical regions in human and nonhuman primates.
Scene-selective cortical regions in human and nonhuman primates.
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DOI：
10.1523/jneurosci.2792-11.2011
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发表时间：
2011-09-28
期刊：
影响因子：
--
通讯作者：
Tootell RB
中科院分区：
文献类型：
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作者：
Nasr S;Liu N;Devaney KJ;Yue X;Rajimehr R;Ungerleider LG;Tootell RB
功能磁共振成像研究揭示了人类视觉皮层中的三个场景选择区域（海马旁位置区（PPA），枕横沟（TOS）和脾后皮质（RSC）），它们与导航，场景感知/识别和上下文关联等高阶功能有关。在这里，我们记录相应的（假定同源）场景选择区域在清醒的猕猴，直接比较人类地图的基础上，使用相同的刺激和功能磁共振成像程序在很大程度上重叠。在人类中，我们的研究结果表明，这三个场景选择区域的中心靠近-但不同于-它们最初命名的脑回/脑沟。此外，所有这些区域都位于已知的视网膜定位区域内或附近。人类RSC和PPA分别位于初级和次级视觉皮层的外周代表附近。人TOS位于视网膜定位区V3 A的正前方/腹侧，在视网膜定位区LO-1、V3 B和/或V7内。与人类区域FFA和PPA（在皮质中彼此相邻）的排列相似，人类PPA的假定猴同源物位于人类FFA的猴同源物附近，靠近后上级颞沟。猴子TOS包括从人类图谱（猕猴V4 d）预测的区域，延伸到视网膜定位定义的V3 A。一个可能的猴同源物的人RSC位于内侧银行，附近的周边V1。总的来说，我们的研究结果表明，人类和非人类灵长类动物的视觉皮层中的场景选择区域具有同源的神经结构，类似于这两个物种中早期展示的面部选择区域。
FMRI studies have revealed three scene-selective regions in human visual cortex (the Parahippocampal Place Area (PPA), Transverse Occipital Sulcus (TOS) and RetroSplenial Cortex (RSC)), which have been linked to higher-order functions such as navigation, scene perception/recognition, and contextual association. Here, we document corresponding (presumptively homologous) scene-selective regions in the awake macaque monkey, based on direct comparison to human maps, using identical stimuli and largely overlapping fMRI procedures. In humans, our results showed that the three scene-selective regions are centered near - but distinct from - the gyri/sulci for which they were originally named. In addition, all these regions are located within or adjacent to known retinotopic areas. Human RSC and PPA are located adjacent to the peripheral representation of primary and secondary visual cortex, respectively. Human TOS is located immediately anterior/ventral to retinotopic area V3A, within retinotopic regions LO-1, V3B, and/or V7. Mirroring the arrangement of human regions FFA and PPA (which are adjacent to each other in cortex), the presumptive monkey homologue of human PPA is located adjacent to the monkey homologue of human FFA, near the posterior superior temporal sulcus. Monkey TOS includes the region predicted from the human maps (macaque V4d), extending into retinotopically-defined V3A. A possible monkey homologue of human RSC lies in the medial bank, near peripheral V1. Overall, our findings suggest a homologous neural architecture for scene-selective regions in visual cortex of humans and non-human primates, analogous to the face-selective regions demonstrated earlier in these two species.