Cholinergic 'blockade' as a model of the cognitive deficits in Alzheimer's disease.
Cholinergic 'blockade' as a model of the cognitive deficits in Alzheimer's disease.
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胆碱能“封锁”作为阿尔茨海默病认知缺陷的模型。
DOI：
10.1093/brain/115.6.1681
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
G. Broe
中科院分区：
文献类型：
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作者：
H. Christensen;N. Maltby;Anthony F Jorm;H. Creasey;G. Broe
44名阿尔茨海默病患者和33名对照者的表现进行了检查，以前发现东莨菪碱管理的差异影响的测试。包括次级记忆、操作智力、初级记忆、语义提取、程序记忆和言语智力。研究发现，阿尔茨海默病患者在次级记忆测试中的表现比对照组更差，这些测试是通过选择性提醒、回忆和识别来衡量的。程序性记忆，如干完成，同音字拼写和转换文本阅读，没有阿尔茨海默病患者和对照组之间的差异。中、重度病例的语义记忆、言语智力和初级记忆受损。然而，通过简易精神状态检查，患有“轻度”痴呆症的患者在语义记忆、言语智力和初级记忆测试中与对照组没有差异。得出的结论是，轻度痴呆症的顺行性记忆缺陷和保存能力的模式模仿以前观察到的东莨菪碱管理的年轻受试者。
The performance of 44 Alzheimer patients and 33 controls was examined on tests previously found to be differentially affected by scopolamine administration. Tests of secondary memory, performance intelligence, primary memory, semantic retrieval, procedural memory and verbal intelligence were included. It was found that Alzheimer patients performed more poorly than controls on tests of secondary memory, as measured by selective reminding, recall and recognition. Procedural memory, as measured by stem completion, homophone spelling and transformed text reading, did not differ between Alzheimer patients and controls. Semantic memory, verbal intelligence and primary memory were impaired in moderate and severe cases. However, patients with 'mild' dementia, as measured by the Mini-Mental State Examination, did not differ from controls on tests of semantic memory, verbal intelligence and primary memory. It was concluded that the pattern of anterograde memory deficits and preserved abilities in mild dementia mimicked that previously observed in scopolamine administration in young subjects.