The incidence of factor VIII and factor IX inhibitors in the hemophilia population of the UK and their effect on subsequent mortality, 1977-99
The incidence of factor VIII and factor IX inhibitors in the hemophilia population of the UK and their effect on subsequent mortality, 1977-99
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DOI：
10.1046/j.1538-7836.2004.00710.x
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发表时间：
2004-07-01
影响因子：
10.4
通讯作者：
Hay, CRM
中科院分区：
文献类型：
--
作者：
Darby, SC;Keeling, DM;Hay, CRM
背景：以前关于抑制剂的发展及其对死亡率影响的研究很少。目的：研究抑制物在英国血友病患者中的发展及其对随后死亡率的影响。患者：1977-98年，在UV、血友病中心医生组织数据库中登记的6078例男性血友病A和1172例男性血友病B。结果：在重度血友病A中，抑制物的发生率分别为34.4、5.2和3.8/1000岁。
Background: Previous Studies of the development of inhibitors and their impact on mortality have been small. Objectives: To examine the development of inhibitors in people with hemophilia in the UK and their effect on subsequent mortality. Patients: 6078 males with henophilia A and 1172 males with hemophilia B registered in the UV, Haemophilia Centre Doctors' Organisation database, 1977-98. Results: In severe hemophilia A inhibitors developed at rates of 34.4, 5.2 and 3.8 per 1000 years at ages