Oxidative Stress: A Promising Target for Chemoprevention.
Oxidative Stress: A Promising Target for Chemoprevention.
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DOI：
10.1007/s40495-016-0052-3
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发表时间：
2016-04
影响因子：
--
通讯作者：
Damodaran C
中科院分区：
文献类型：
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作者：
John AS;Ankem MK;Damodaran C
癌症是全球死亡的主要原因，治疗晚期癌症仍然具有临床挑战性。流行病学研究表明，氧化剂和自由基引起的DNA损伤是肿瘤发病的主要因素之一。因此，氧化剂是化学预防和治疗的有吸引力的靶点。已知膳食剂发挥抗氧化特性，这是癌症进展中最有效的预防策略之一。在这篇文章中，我们强调饮食制剂可以潜在地靶向氧化应激，从而延迟，预防或治疗癌症的发展。其中一些药物目前正在基础研究中使用，而一些药物已成功进入临床试验。
Cancer is a leading cause of death worldwide, and treating advanced stages of cancer remains clinically challenging. Epidemiological studies have shown that oxidants and free radicals induced DNA damage is one of the predominant causative factors for cancer pathogenesis. Hence, oxidants are attractive targets for chemoprevention as well as therapy. Dietary agents are known to exert an anti-oxidant property which is one of the most efficient preventive strategy in cancer progression. In this article, we highlight dietary agents can potentially target oxidative stress, in turn delaying, preventing, or treating cancer development. Some of these agents are currently in use in basic research, while some have been launched successfully into clinical trials.