APOLIPOPROTEIN-A-I AND APOLIPOPROTEIN-B AND CHOLESTEROL IN SYNOVIAL-FLUID OF PATIENTS WITH RHEUMATOID-ARTHRITIS
APOLIPOPROTEIN-A-I AND APOLIPOPROTEIN-B AND CHOLESTEROL IN SYNOVIAL-FLUID OF PATIENTS WITH RHEUMATOID-ARTHRITIS
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DOI：
10.1016/0026-0495(93)90050-x
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发表时间：
1993-07-01
影响因子：
9.8
通讯作者：
KASHYAP, ML
中科院分区：
文献类型：
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作者：
ANANTH, L;PRETE, PE;KASHYAP, ML
类风湿性关节炎（RA）患者的滑液（SF）已被注意到含有胆固醇晶体，与正常SF相比，胆固醇含量增加。分析12例未经治疗的典型类风湿性关节炎（炎症性关节炎）和8例未经治疗的退行性关节疾病（[DJD]非炎症性关节炎）患者的SF、血浆载脂蛋白（apos） A-I、B和胆固醇。结果显示，RA SF患者的平均载脂蛋白A-I、载脂蛋白B和胆固醇水平显著高于DJD SF患者（载脂蛋白A-I，P= 0.004；载脂蛋白B，P= 0.008；胆固醇，P= 0.004）。血浆和SF载脂蛋白A-I和载脂蛋白B （r= 0.72，P= 0.008和r= 0.63，P= 0.02）的回归分析表明，这些脂蛋白成分通过RA滑膜的通透性增加，而在DJD滑膜中没有观察到。这些数据表明，RA滑膜对低脂蛋白和高密度脂蛋白（LDL和HDL）的主要载脂蛋白更具渗透性，而DJD滑膜则没有。这些载脂蛋白已被证明影响免疫反应，因此可能参与RA的发病机制。
Synovial fluid (SF) of patients with rheumatoid arthritis (RA) has been noted to contain cholesterol crystals and increased amounts of cholesterol compared with normal SF. SF, plasma apolipoproteins (apos) A-I and B, and cholesterol in 12 untreated classic RA patients (inflammatory arthritis) and eight untreated degenerative joint disease ([DJD] noninflammatory arthritis) patients were analyzed. Results showed that mean apo A-I, apo B, and cholesterol levels of RA SF were significantly higher than those of DJD SF (apo A-I,P= .004; apo B,P= .0008; cholesterol,P= .0004). Regression analyses of plasma and SF apo A-I and apo B (r= .72,P= .008 andr= .63,P= .02, respectively) suggested an increased permeability for these lipoprotein constituents across RA synovial membrane that was not observed in DJD synovial membrane. These data suggest that RA synovium but not DJD synovium is more permeable to major apoproteins of low- and high-density lipoproteins (LDL and HDL). These apolipoproteins have been shown to influence the immune response and may therefore be involved in the pathogenesis of RA.